Effects of cerebellar magnetic stimulation on chronic post-lateral medullary infarction dizziness: A proof-of-principle cohort study

• Published in: Journal of the neurological sciences Vol. 392; pp. 56 - 62
• Main Authors: Johkura, Ken, Kudo, Yosuke, Sugawara, Eriko, Watanabe, Kosuke, Nakamizo, Tomoki, Yamamoto, Masahiro, Amari, Kazumitsu, Takahashi, Koji, Tanaka, Osamu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.09.2018
• Subjects: Adult; Aged; Cerebellum; Cerebellum - physiology; Cohort Studies; Dizziness; Dizziness - complications; Dizziness - therapy; Female; Functional Laterality - physiology; Humans; Infarction - complications; Infarction - therapy; Lateral medullary infarction; Male; Medulla Oblongata - blood supply; Middle Aged; Nystagmus, Pathologic - therapy; Reflex, Vestibulo-Ocular - physiology; Repetitive transcranial magnetic stimulation; Time Factors; Transcranial Magnetic Stimulation - methods; Treatment Outcome; Vestibulo-ocular reflex; Young Adult; Dizziness; Cerebellum; Repetitive transcranial magnetic stimulation; Lateral medullary infarction; Vestibulo-ocular reflex
• ISSN: 0022-510X; 1878-5883
• DOI: 10.1016/j.jns.2018.07.007

Lateral medullary infarction (LMI) sometimes causes long-lasting dizziness. Although the precise mechanism of chronic post-LMI dizziness is unknown, a cerebellar control disorder of the vestibulo-ocular reflex (VOR) has been reported in such patients. We conducted a proof-of-principle cohort study to assess the potential efficacy of cerebellar repetitive transcranial magnetic stimulation (rTMS) as treatment for chronic post-LMI dizziness. We first applied cerebellar rTMS in healthy volunteers (n = 11) and showed that cerebellar intermittent theta burst stimulation (iTBS) affected vestibulocerebellar neural activity. Then, between September and December 2015, we enrolled six patients (aged≥20 years) with chronic post-LMI dizziness (duration≥6 months), applied cerebellar rTMS (iTBS for 5 days), and followed these patients up for up to 25 months for clinical symptoms (Dizziness Handicap Inventory [DHI]), signs (nystagmus), and VOR gain. Four of the six patients completed the study without complications. After rTMS, DHI scores were reduced (mean pre-rTMS DHI score minus post-rTMS DHI score was 13.0 [P = 0.036]) with disappearance of the ipsilesional nystagmus characteristic of the post-LMI dizziness. Reduction in the absolute VOR gain (mean pre- rTMS gain minus post-rTMS gain in the ipsilesional direction was 0.135 [P = 0.036] and that in the contralesional direction was 0.137 [P = 0.031]) were also associated with reduced DHI scores. Relative cerebellar blood flow to the brainstem was increased in four of five patients. The effects of cerebellar rTMS did not always persist, and three of four patients elected to undergo more than one rTMS series. The repeat cerebellar rTMS treatments had same beneficial effects. Our study showed, for the first time, the potential efficacy of cerebellar rTMS for treatment of chronic post-LMI dizziness. The short duration of the cerebellar rTMS effects can be compensated for by repeating the rTMS treatment every few months. Further large-scale randomized studies are warranted to confirm our findings. •Lateral medullary infarction (LMI) sometimes causes long-lasting dizziness.•This is the first proof-of-principle cohort study on post-LMI dizziness treatment.•Cerebellar rTMS appears to be effectual for treatment of post-LMI dizziness.•The effects of cerebellar rTMS appear to be of short duration.•The impermanence can be compensated for by repeating the rTMS treatment.