Association of HLA class I alleles with aloplecia areata in Chinese Hans

• Published in: Journal of dermatological science Vol. 41; no. 2; pp. 109 - 119
• Main Authors: Xiao, Feng-Li, Yang, Sen, Yan, Kai-lin, Cui, Yong, Liang, Yan-Hua, Zhou, Fu-Sheng, Du, Wen-Hui, Gao, Min, Sun, Liang-Dan, Fan, Xing, Chen, Jian-Jun, Wang, Pei-Guang, Zhu, Ya-Gang, Zhou, Shun-Ming, Zhang, Xue-Jun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.02.2006
• Subjects: Adolescent; Adult; Age of Onset; Aged; Alleles; Alopecia Areata - epidemiology; Alopecia Areata - genetics; Alopecia Areata - immunology; Aloplecia areata; Asian Continental Ancestry Group - genetics; Child; Child, Preschool; China - epidemiology; DNA - genetics; Female; Gene Frequency; Genes, MHC Class I; Haplotype; Haplotypes; HLA; HLA-A2 Antigen - genetics; HLA-A3 Antigen - genetics; HLA-B27 Antigen - genetics; Humans; Male; Middle Aged; Phenotype; Polymerase Chain Reaction; Polymerase chain reaction-sequence-specific primer; Severity of Illness Index; China; Polymerase chain reaction-sequence-specific primer; HLA; Aloplecia areata; Haplotype
• ISSN: 0923-1811; 1873-569X
• DOI: 10.1016/j.jdermsci.2005.07.008

Some studies suggested that human HLA status may potentiate development of the AA phenotype and exists ethic differences. No report has been published about HLA class I alleles associated with AA in Chinese Hans. To study the distribution of HLA class I alleles and haplotypes in Chinese Hans AA patients and the relation of HLA class I profile with age of onset, severity, duration of current attack, past history and family history. The polymerase chain reaction-sequence-specific primer (PCR-SSP) method was used to analyze the distribution of HLA class I alleles in 192 patients with AA and 252 healthy controls in Chinese Hans. The frequencies of HLA-A*02, -A*03, -B*18, -B*27, -B*52 and -Cw*0704 were significantly higher in patients than in controls. The A*2-B*18, A*2-B*27, A*2-B*52, A*2-Cw*0704, B*18-Cw*0704, B*27-Cw*0704, B*52-Cw*0704 were found as high-risk haplotypes in developing AA in this study. The HLA-A*02 and -A*03 were observed increased frequencies in patients less than 50% hair loss, and HLA-B*27 equally in patients of 50–99% hair loss, alopecia totalis and alopecia universalis. The frequencies of HLA-A*02 and -B*27 were significantly raised in recurrent patients, and ones of HLA-A*02, -A*03 and -B*27 similarly in patients without a positive family history. This study demonstrated the positive association of HLA class I alleles and haplotypes with AA. There may be differences in genetic background in patients with different age of onset, grade of scalp hair loss, duration of current attack, a past history and a family history.