Enhancement of the antibiotic activity of erythromycin by volatile compounds of Lippia alba (Mill.) N.E. Brown against Staphylococcus aureus

• Published in: Pharmacognosy Magazine Vol. 7; no. 28; pp. 334 - 337
• Main Authors: Veras, Helenicy N H, Campos, Adriana R, Rodrigues, Fabíola F G, Botelho, Marco A, Coutinho, Henrique D M, Menezes, Irwin R A, da Costa, José Galberto M
• Format: Journal Article
• Language: English
• Published: United States Sage Publications Ltd 01.10.2011; Medknow Publications & Media Pvt Ltd
• Subjects: Antimicrobial agents; Bacteria; Microbiology; Natural products; Original; Respiratory system; Studies; Lippia alba; Chemical composition; essential oil; modulatory activity; erythromycin
• ISSN: 0973-1296; 0976-4062
• DOI: 10.4103/0973-1296.90415

Lippia alba (Mill.) N.E. Brown, popularly known as "erva-cidreira," is commonly found in northeastern Brazil. The leaves tea is used to treat digestive disturbances, nausea, cough, and bronchitis. This work reports the chemical composition and erythromycin-modifying activity by gaseous contact against Staphylococcus aureus. The leaves of L. alba were subjected to hydrodistillation, and the essential oil extracted was examined with respect to the chemical composition, by gas chromatography-mass spectrometry (GC-MS), and the essential oil extracted was evaluated for antibacterial and antibiotic-modifying activity by gaseous contact. The overall yield of essential oil obtained by hydrodistillation was 0.52%. The GC-MS analysis has led to the identification of the main components: geranial (31.4%) and neral (29.5%). It was verified that the essential oil interfered with erythromycin antibiotic activity against S. aureus ATCC 25923 was enhanced (221.4%) in the presence of 12% essential oil. The 3% essential oil increased the effect against S. aureus ATCC 25923 (41.6%) and S. aureus ATCC 6538 (58.3%). The essential oil of L. alba influences the activity of erythromycin and may be used as an adjuvant in antibiotic therapy against respiratory tract bacterial pathogens. The essential oil of L. alba influences the activity of erythromycin and may be used as an adjuvant in antibiotic therapy against respiratory tract bacterial pathogens.