New lignan esters from Alyxia schlechteri and antifungal activity against Pythium insidiosum

• Published in: Fitoterapia Vol. 91; pp. 39 - 43
• Main Authors: Sriphana, Uraiwan, Thongsri, Yordhathai, Ardwichai, Pispong, Poopasit, Kitisak, Prariyachatigul, Chularut, Simasathiansophon, Sontaya, Yenjai, Chavi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2013
• Subjects: Alyterinates A−C; Alyxia; Alyxia schlechteri; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; antifungal properties; Apocynaceae - chemistry; cell walls; ergosterol; esters; fungi; Lignans; Lignans - isolation & purification; Lignans - pharmacology; mycelium; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Roots - chemistry; Pythium - drug effects; Pythium insidiosum; roots; Alyterinates A−C; Pythium insidiosum; Alyxia schlechteri; Lignans
• ISSN: 0367-326X; 1873-6971
• DOI: 10.1016/j.fitote.2013.08.005

Three new lignan esters, alyterinates A–C (1−3), as well as 10 known compounds were isolated from the roots of Alyxia schlechteri. Antifungal activity against Pythium insidiosum of all lignan derivatives was evaluated using disk diffusion assay. P. insidiosum is not a true fungus since its cell walls do not contain ergosterol as usual fungi, so the antifungals available now are not effective. From activity testing, it was found that compounds 3, 4 and 5 could inhibit the mycelia growth of P. insidiosum. [Display omitted]