Pathophysiology of Chronic Venous Disease and Venous Ulcers

Chronic venous disease and venous leg ulceration are a common disease affecting millions of individuals. The fundamental problem is venous hypertension with resultant clinical manifestations of venous disease including varicose veins, skin changes, and venous leg ulceration. The pathophysiology lead...

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Bibliographic Details
Published inThe Surgical clinics of North America Vol. 98; no. 2; p. 337
Main Author Raffetto, Joseph D
Format Journal Article
LanguageEnglish
Published United States 01.04.2018
Subjects
Chronic venous disease
Glycocalyx
Matrix metalloproteinases
Cytokines
Venous leg ulcers
Endothelial dysfunction
Adhesion molecules
Inflammation
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Summary:Chronic venous disease and venous leg ulceration are a common disease affecting millions of individuals. The fundamental problem is venous hypertension with resultant clinical manifestations of venous disease including varicose veins, skin changes, and venous leg ulceration. The pathophysiology leading to venous hypertension is complex and multifactorial, involving genetic predisposition, environmental factors, hormones, endothelial dysfunction, inflammatory cells and molecules and activation on the endothelium and vein wall, and disturbances in the balance of cytokines and matrix metalloproteinases. Understanding the pathophysiology of chronic venous disease and venous leg ulcers identifies cellular pathways, biomarkers, metabolic signatures, and cellular cross-talk for targeted therapy.
ISSN:1558-3171
DOI:10.1016/j.suc.2017.11.002