Evaluation of biocomposite films containing alginate and sago starch impregnated with silver nano particles

• Published in: Carbohydrate polymers Vol. 90; no. 1; pp. 717 - 724
• Main Authors: Marie Arockianathan, P., Sekar, S., Sankar, S., Kumaran, B., Sastry, T.P.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.09.2012; Elsevier
• Subjects: Alginates - chemistry; Alginates - pharmacology; Animals; Applied sciences; biocomposites; Biological and medical sciences; Composites; Drug Evaluation, Preclinical - methods; Exact sciences and technology; films (materials); Forms of application and semi-finished materials; gentamicin; Glucuronic Acid - chemistry; Glucuronic Acid - pharmacology; Hexuronic Acids - chemistry; Hexuronic Acids - pharmacology; histopathology; Male; mechanical properties; Medical sciences; Metal Nanoparticles - chemistry; Nanocomposite; nanoparticles; nanosilver; Oryza; Polymer industry, paints, wood; polymers; Rats; Rats, Wistar; sago; Sago starch; scanning electron microscopy; Silver - chemistry; Silver - pharmacology; Silver nano particle; Sodium alginate; solvents; Starch - chemistry; Starch - pharmacology; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology of polymers; Technology. Biomaterials. Equipments; transmission electron microscopy; Wound dressing; Wound Healing - drug effects; Wound Healing - physiology; Nanocomposite; Wound dressing; Sodium alginate; Sago starch; Silver nano particle; Mixing; Rat; Porous material; Wound; Chemical reduction; Dressing; Silver sulfate; Biomaterial; Manufacturing; Cicatrization; Growth from solution; Polymer blends; Starch; Rodentia; Mechanical properties; Histology; Alginates; Experimental study; Metal particle; Silver; In vivo; Vertebrata; Mammalia; Animal; Oside polymer; Antibacterial agent
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2012.06.003

► A novel composite film containing sago starch and alginate impregnated with silver nanoparticles was prepared. ► This is a natural composite which has wound healing properties. ► The preparation of alginate and sago starch composite is cheaper and affordable for common man in third world countries. In recent years, the metal nanoparticles/polymer composites have created lot of attraction due to their wide range of applications. In the present study, the composite films of alginate (AL) and sago starch (SG) impregnated with silver nano particles (AgNP) with and without antibiotic gentamicin (G) were prepared by solvent casting method. The films prepared were characterized for thermo gravimetric analysis, SEM, TEM and mechanical properties and the results have shown the composite nature of the films. AL–SG–AgNP and AL–SG–AgNP–G composites were used as wound dressing materials in experimental wounds of rats. The healing pattern of the wounds was evaluated by planimetric studies, macroscopic observations, biochemical studies and histopathological observations. The results have shown faster healing pattern in the wounds treated with AL–SG–AgNP and AL–SG–AgNP–G composites compared to untreated control. This study revealed that AL–SG–AgNP film might be a potential and economical wound dressing material.