The influence of the noradrenergic/stress system on perceptual biases for reward

• Published in: Cognitive, affective, & behavioral neuroscience Vol. 19; no. 3; pp. 715 - 725
• Main Authors: Ehlers, M. R., Ross, C. J. D., Todd, R. M.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2019; Springer Nature B.V
• Subjects: a2-Adrenergic receptors; Behavioral Science and Psychology; Bias; Cognitive Psychology; Emotions; Flexibility; Influence; Kinases; Memory; Neurosciences; Norepinephrine; Psychology; Punishment; Reinforcement; Emotion; Reward; Motivation; Norephinephrine
• ISSN: 1530-7026; 1531-135X
• DOI: 10.3758/s13415-018-00657-0

Previous research has established a role for the norepinephrine (NE)/stress system in individual differences in biases to attend to reward or punishment. Outstanding questions concern its role in the flexibility with which such biases can be changed. The goal of this preregistered study was to examine the role of the NE/stress system in the degree to which biases can be trained along the axis of valence in the direction of reward. Participants genotyped for a common deletion variant of ADRA2b (linked to altered NE availability) experienced either an acute stress induction or a control procedure. Following stress induction, a “bias probe” task was presented before and after training. In the bias probe task, participants made forced choice judgments (happy or angry) on emotional faces with varying degrees of ambiguity. For bias training, participants viewed unambiguously angry faces in a task exploiting visual adaptation effects. The results revealed an overall shift from a slightly positive bias in categorizing faces pretraining to a more positive bias after training. Carriers of the deletion variant overall showed a more positive bias than did the noncarriers. Follow-up analyses showed that pretraining bias was a significant predictor of bias change, with those who showed a more negative bias preadaptation changing more in a positive direction. Critically, this effect was observed under control but not under stress conditions. These results suggest that the NE/stress system plays an important role in influencing trait-like biases as well as short-term changes in the tendency to perceive ambiguous stimuli as being more rewarding than threatening.