Generation of Parkinson’s disease patient-derived human induced pluripotent stem cells line (PNUSCRi001-A) carrying a N227S mutation in GBA gene

The hiPSC line was generated from peripheral blood mononuclear cells (PBMCs) collected by a male patient with young onset Parkinson’s disease, carrying on heterozygous c.680 A > G (N227S) mutation in the GBA gene. The PBMCs was reprogrammed into an induced pluripotent stem cell (iPSC) line (PNUSC...

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Published inStem cell research Vol. 65; p. 102959
Main Authors Lee, Nayeon, Moon, Hye-Ji, Park, So-Hyun, Moon, Ji-Young, Park, Ka-Kyung, Kim, Jae-Ho, Lee, Jae-Hyeok
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.12.2022
Elsevier
Subjects
Humans
Induced Pluripotent Stem Cells
Leukocytes, Mononuclear
Male
Mutation - genetics
Parkinson Disease - genetics
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Summary:The hiPSC line was generated from peripheral blood mononuclear cells (PBMCs) collected by a male patient with young onset Parkinson’s disease, carrying on heterozygous c.680 A > G (N227S) mutation in the GBA gene. The PBMCs was reprogrammed into an induced pluripotent stem cell (iPSC) line (PNUSCRi001-A hiPSCs) using non-integrative sendai virus. The hiPSC line, PNUSCRi001-A displayed a normal karyotype and the Expression of pluripotency markers that is capable of producing derivatives of three germ layers (Ectoderm, Endoderm and Mesoderm).
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ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2022.102959