Multilayered textile coating based on a β-cyclodextrin polyelectrolyte for the controlled release of drugs

• Published in: Carbohydrate polymers Vol. 93; no. 2; pp. 718 - 730
• Main Authors: Martin, Adeline, Tabary, Nicolas, Leclercq, Laurent, Junthip, Jatupol, Degoutin, Stéphanie, Aubert-Viard, François, Cazaux, Frédéric, Lyskawa, Joël, Janus, Ludovic, Bria, Marc, Martel, Bernard
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 02.04.2013; Elsevier
• Subjects: anions; Applied sciences; aqueous solutions; Benzoates - chemistry; beta-cyclodextrin; beta-Cyclodextrins - chemistry; bioactive properties; Biological and medical sciences; cations; Chitosan; Chitosan - chemistry; coatings; colorimetry; Cyclodextrin polymer; Delayed-Action Preparations - chemistry; Drug Carriers - chemistry; Drug release system; drugs; electrolytes; Exact sciences and technology; fabrics; Fibers and threads; Forms of application and semi-finished materials; General pharmacology; gravimetry; Kinetics; Layer-by-layer; Medical sciences; microscopy; Non-woven textile; OWLS; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; polyethylene terephthalates; Polyethylene Terephthalates - chemistry; Polymer industry, paints, wood; pretreatment; Technology of polymers; Textiles; titration; Cyclodextrin polymer; OWLS; Chitosan; Non-woven textile; Layer-by-layer; Drug release system; Self-assembled layer; Ethylene terephthalate polymer; Self assembly; Synthetic fiber; Drug carrier; Benzoic acid derivatives; Crosslinked polymer; Electrokinetic potential; Dip coating; Release; Carboxylate polymer; Coating material; Control release polymer; Multiple layer; Chemical pretreatment; Crosslinking; Experimental study; Citric acid; Polyelectrolyte; Cyclodextrin; Morphology; Coated fabric; Oside polymer; Kinetics; Woven material; Inclusion compound
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2012.12.055

► Layer by layer process on a non-woven PET using chitosan and a polymer of cyclodextrins ► Building of a multilayer assembly up to 20 layers ► Visible deposition at the surface with charge alternation ► Effective encapsulation and release of a model molecule up to 40 days ► Release dependant on the layer number on the surface. The aim of this work was to develop the formation of multilayered coating incorporating a cyclodextrin polyelectrolyte onto a non-woven polyethylene terephthalate (PET) textile support in order to obtain reservoir and sustained release properties towards bioactive molecules. We optimized the multilayer assembly immobilization onto the PET surface according to the layer-by-layer (LbL) deposition process. After a pre-treatment of the textile support aiming to offer a sufficient ionic character to the surface, it was alternatively immersed into two polyelectrolytes aqueous solutions consisting of chitosan (CHT) as polycation on the one hand, and a β-cyclodextrin polymer (polyCTR-βCD) as polyanion on the other hand. In a second approach, a TBBA/polyCTR-βCD complex (4-tert-butylbenzoic acid, TBBA) was used in order to load the system with a drug model whose kinetics of release was assessed. Gravimetry, microscopy, OWLS, colorimetric titration, infrared and zetametry were used as characterization techniques. An effective deposition on the textile surface due to ionic interactions with alternation of up to 10 layers of each of both polyelectrolytes was clearly evidenced. However, we observed that layer formation occurred to a lesser extent when TBBA/polyCTR-βCD complex was applied instead of polyCTR-βCD alone. The release study showed that drug reservoir properties and release kinetics could be controlled by the number of layers in the system and that TBBA release was faster than the multilayered coating degradation.