Alzheimer's disease and anesthesia

Cognitive disorders such as postoperative cognitive dysfunction, confusion, and delirium, are common following anesthesia in the elderly, with symptoms persisting for months or years in some patients. Alzheimer's disease (AD) patients appear to be particularly at risk of cognitive deterioration...

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Published inFrontiers in neuroscience Vol. 4; p. 272
Main Authors Papon, Marie-Amélie, Whittington, Robert A, El-Khoury, Noura B, Planel, Emmanuel
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 01.01.2011
Frontiers Media S.A
Subjects
Age
Alzheimer's disease
Amyloid
Anesthesia
Anesthesiology
Anesthetics
Apoptosis
Biomarkers
Cognitive ability
Delirium
Dementia
Enzymes
Geriatrics
Heart surgery
Hospital costs
Hypothermia
Kinases
Neurodegenerative diseases
Neuroscience
Older people
Patients
Proteins
Studies
Tau phosphorylation
amyloid
tau phosphorylation
hypothermia
Alzheimer's disease
anesthesia
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Summary:Cognitive disorders such as postoperative cognitive dysfunction, confusion, and delirium, are common following anesthesia in the elderly, with symptoms persisting for months or years in some patients. Alzheimer's disease (AD) patients appear to be particularly at risk of cognitive deterioration following anesthesia, and some studies suggest that exposure to anesthetics may increase the risk of AD. Here, we review the literature linking anesthesia to AD, with a focus on the biochemical consequences of anesthetic exposure on AD pathogenic pathways.
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Reviewed by: Jesus Avila, Centro de Biología Molecular Severo Ochoa CSIC-UAM, Spain; Cheng-Xin Gong, The City University of New York, USA
This article was submitted to Frontiers in Neurodegeneration, a specialty of Frontiers in Neuroscience.
Edited by: David J. Loane, University of Maryland School of Medicine, USA
ISSN:1662-4548
1662-453X
1662-4548
DOI:10.3389/fnins.2010.00272