Renal handling of calcium and phosphorus in experimental renal hyperparathyroidism in dogs

• Published in: Veterinary research (Paris) Vol. 34; no. 4; pp. 379 - 387
• Main Authors: Garcia-Rodriguez, M.B. ((Universidad de Leon (Espagne). Faculdad de Veterinaria, Departamento de Medicina Veterinaria)), Perez-Garcia, C.C, Rios-Granja, M.A, Cano-Rabano, M.J, Pena-Penabad, M, Gallego-Morales, D, Garcia-Partida, P, Diez-Prieto, I
• Format: Journal Article
• Language: English
• Published: Les Ulis EDP Sciences 01.07.2003; BioMed Central
• Subjects: Analysis of Variance; Animal biology; Animal genetics; Animals; Biochemistry, Molecular Biology; Biological and medical sciences; CALCIO; CALCITONIN; Calcitonin - blood; CALCITONINA; CALCITONINE; CALCIUM; Calcium - blood; Calcium - urine; Cell Behavior; Cellular Biology; CHIEN; Creatinine - blood; Creatinine - urine; Dog Diseases - blood; Dog Diseases - urine; DOGS; ENDOCRINE DISEASES; Endocrinopathies; ENFERMEDADES GLANDULAS ENDOCRINAS; Female; FOSFORO; Genetics; GLANDULA PARATIROIDE; Hyperparathyroidism - blood; Hyperparathyroidism - urine; Hyperparathyroidism - veterinary; Immunology; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - urine; Kidney Failure, Chronic - veterinary; Kidney Function Tests - veterinary; KIDNEYS; Life Sciences; Male; Medical sciences; Microbiology and Parasitology; Molecular biology; Neurons and Cognition; Non tumoral diseases. Target tissue resistance. Benign neoplasms; ORINA; PARATHYROID GLAND; Parathyroid Hormone - blood; PARATHYROIDE; PERRO; PHOSPHORE; PHOSPHORUS; Phosphorus - blood; Phosphorus - urine; Random Allocation; REIN; RINONES; Santé publique et épidémiologie; Sodium - blood; Sodium - urine; Thyroid. Thyroid axis (diseases); TROUBLE ENDOCRINIEN; Urinalysis - veterinary; URINE; Endocrinopathy; Fissipedia; Carnivora; Calcium; Phosphorus; Inorganic element; renal hyperparathyroidism; calciuria; Vertebrata; Mammalia; Parathyroid diseases; Parathyroid hormone; Calcitonin; Thyroid hormone; Veterinary; Dog; Hyperparathyroidism; phosphaturia; parathyroid hormone; calcitonin; dog
• ISSN: 0928-4249; 1297-9716
• DOI: 10.1051/vetres:2003015

Twenty-four hour urinary excretion, fractional excretion and the filtered load of calcium and phosphorus were monitored as hyperparathyroidism evolved in a model of progressive canine renal failure. Thirteen beagles of both sexes aged four and a half months were used. Nine of them were subjected to a renal damaging schedule (neomycine, 60 mg/kg/48 h, IM, 32 weeks) in order to induce chronic renal failure leading to secondary hyperparathyroidism (2HPT group). The remaining four were kept as the control group. The experiment was conducted over 32 weeks. Blood and 24 h urine were collected every four weeks. Calcium, phosphorus and creatinine were analyzed. Plasma parathormone and calcitonin were determined at weeks 0, 12, 24 and 32. The level of renal function in the 2HPT animals was reduced to 25 percent of that of the controls (endogenous creatinine clearance was 0.45 +/- 0.22 mL/min/kg as opposed to 1.81 +/- 0.54 mL/min/kg). Hyperparathyroidism was confirmed by a progressive increase in the levels of the parathyroid hormone. Calcitonin levels were not modified. A tendency to hypocalcaemia was observed, reaching statistically significant levels from the twenty-eighth week of the study, when hyperphosphataemia also became significant. Daily urinary excretion of calcium and phosphorus remained at values considered normal throughout the experiment with no alteration imputable to the impaired renal function. This is explained by the decrease in the filtered load of these elements (in both cases statistically significant from the 24. week on) being associated with an increase in their fractional excretion. Thus, calcium and phosphorus urinary excretion values could be maintained in a normal range up to the end of the experiment, showing that renal calcium handling in dogs with experimentally induced renal failure seems to differ from that observed in human patients