Longitudinal, transverse, and diffuse nail hyperpigmentation induced by hydroxyurea

Hydroxyurea is a cytostatic agent used in patients with myeloproliferative disorders that may produce nail hyperpigmentation, most frequently longitudinal melanonychia. We present a patient treated with hydroxyurea whose nails showed several patterns of nail hyperpigmentation, including longitudinal...

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Bibliographic Details
Published inJournal of the American Academy of Dermatology Vol. 41; no. 2; pp. 333 - 334
Main Authors Hernández-Martín, Angela, Ros-Forteza, Santiago, de Unamuno, Pablo
Format Journal Article
LanguageEnglish
Published New York, NY Mosby, Inc 01.08.1999
Elsevier
Subjects
Aged
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Humans
Hydroxyurea - adverse effects
Hydroxyurea - therapeutic use
Hyperpigmentation - chemically induced
Male
Medical sciences
Nail Diseases - chemically induced
Pharmacology. Drug treatments
Thrombocytopenia - drug therapy
Toxicity: skin, dermoskeleton
Human
Antineoplastic agent
Case study
Skin disease
Nail(anatomy)
Pigmentation disorder
Hydroxycarbamide
Toxicity
Nail disease
Hypermelanosis
Elderly
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Summary:Hydroxyurea is a cytostatic agent used in patients with myeloproliferative disorders that may produce nail hyperpigmentation, most frequently longitudinal melanonychia. We present a patient treated with hydroxyurea whose nails showed several patterns of nail hyperpigmentation, including longitudinal and transverse bands, and a diffuse darkening of the nail matrix. (J Am Acad Dermtol 1999;40:333-4.)
ISSN:0190-9622
1097-6787
DOI:10.1016/S0190-9622(99)70379-8