Deadly actin collapse by disulfidptosis

Programmed cell death (PCD) enables cells to co-ordinate their exit to benefit the surviving organism. A new study describes how cells can programme their death by inducing extensive disulfide bonding of the actin cytoskeleton in response to an imbalance of cystine, a raw material for glutathione pr...

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Bibliographic Details
Published inNature cell biology Vol. 25; no. 3; pp. 375 - 376
Main Author Machesky, Laura M.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.03.2023
Nature Publishing Group
Subjects
631/67/2327
631/80
Actin
Actins
Apoptosis
Biochemistry
Biology
Biomedical and Life Sciences
Cancer
Cancer Research
Cell Biology
Cell death
Cells
Chemical bonds
Cytoskeleton
Developmental Biology
Fatty acids
Glucose
Glutathione
Homeostasis
Kinases
Life Sciences
News & Views
news-and-views
Oxidation
Proteins
Raw materials
Stem Cells
Yeast
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Summary:Programmed cell death (PCD) enables cells to co-ordinate their exit to benefit the surviving organism. A new study describes how cells can programme their death by inducing extensive disulfide bonding of the actin cytoskeleton in response to an imbalance of cystine, a raw material for glutathione production.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
content type line 23
ISSN:1465-7392
1476-4679
DOI:10.1038/s41556-023-01100-4