Functionalized hydrazide macrocycle ion channels showing pH-sensitive ion selectivities

Transmembrane channels formed by functionalized hydrazide macrocycles are reported. The different pH values of buffer solutions have a significant effect on the K + /Cl − selectivity of the macrocycles. This unique transport behavior is mainly induced by the different distributions of charges in the...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 53; no. 3; pp. 625 - 628
Main Authors Xin, Pengyang, Tan, Si, Wang, Yaodong, Sun, Yonghui, Wang, Yan, Xu, Yuqing, Chen, Chang-Po
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 2017
Subjects
Buffer solutions
Channels
chemical reactions
Chemistry
Chemistry, Multidisciplinary
chlorides
Hydrazides
Ion channels
Macrocyclic compounds
Physical Sciences
potassium
Science & Technology
Selectivity
Transport
TRANSMEMBRANE CHANNELS
TRANSPORT
MODELS
BILAYER-MEMBRANES
BEHAVIOR
NANOPORES
PORES
DERIVATIVES
GRAMICIDIN-A
BETA-BARRELS
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Summary:Transmembrane channels formed by functionalized hydrazide macrocycles are reported. The different pH values of buffer solutions have a significant effect on the K + /Cl − selectivity of the macrocycles. This unique transport behavior is mainly induced by the different distributions of charges in the tubular channels under various pH values.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/C6CC08943G