Correlation of Cognitive Reappraisal and the Microstructural Properties of the Forceps Minor: A Deductive Exploratory Diffusion Tensor Imaging Study

• Published in: Brain topography Vol. 37; no. 1; pp. 63 - 74
• Main Authors: Porcu, Michele, Cocco, Luigi, Cau, Riccardo, Suri, Jasjit S., Mannelli, Lorenzo, Manchia, Mirko, Puig, Josep, Qi, Yang, Saba, Luca
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2024; Springer Nature B.V
• Subjects: Anisotropy; Biomedical and Life Sciences; Biomedicine; Cognitive ability; Correlation analysis; Emotional regulation; Magnetic resonance imaging; Neuroimaging; Neurology; Neurosciences; Original Paper; Prefrontal cortex; Psychiatry; Statistics; DTI; Forceps minor; Cognitive reappraisal
• ISSN: 0896-0267; 1573-6792; 1573-6792
• DOI: 10.1007/s10548-023-01020-4

Cognitive reappraisal (CR) is a mechanism for emotion regulation, and the prefrontal cortex (PFC) plays a central role in the regulation of emotions. We tested the hypothesis of an association between CR function and microstructural properties of forceps minor (a commissural bundle within the PFC) in healthy subjects (HS). We analyzed a population of 65 young HS of a public dataset. The diffusion tensor imaging (DTI) sequence of every subject was analyzed to extract the derived shape (diameter and volume) and DTI metrics in terms of fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) of the forceps minor. The CR subscale of the German version of the Emotion Regulation Questionnaire (ERQ) was used for CR assessment. The Shapiro–Wilk test was applied to test the assumption of normality in all these parameters, adopting a statistical threshold at p < 0.05. Whenever appropriate a non-parametric two-tailed partial correlation analysis was applied to test for correlations between the CR ERQ score and the derived shape and DTI metrics, including age and sex as confounders, adopting a statistical threshold at p < 0.05. The non-parametric two-tailed partial correlation analysis revealed a mildly significant correlation with FA (ρ = 0.303; p = 0.016), a weakly significant negative correlation with MD (ρ = − 0.269; p = 0.033), and a mildly significant negative correlation with RD (ρ = − 0.305; p = 0.015). These findings suggest a correlation between DTI microstructural properties of forceps minor and CR.