The copper-catalyzed aerobic oxidative amidation of tertiary amines

A general and efficient method for the synthesis of tertiary amides has been developed via the copper-catalyzed aerobic oxidative amidation of tertiary amines. Due to the use of the O 2 oxidant, various functional groups were well tolerated under the present conditions. Extensive substrates studies...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 51; no. 99; pp. 17596 - 17599
Main Authors Cheng, Hui-Cheng, Hou, Wen-Jun, Li, Zeng-Wen, Liu, Ming-Yu, Guan, Bing-Tao
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2015
Subjects
Amides
Amines
catalytic activity
chemical reactions
Chemistry
Chemistry, Multidisciplinary
Functional groups
Oxidants
Oxidizing agents
oxygen
Physical Sciences
Science & Technology
Synthesis
tertiary amines
ORGANIC-SYNTHESIS
METAL ACETATES
4-SUBSTITUTED N,N-DIALKYLANILINES
COUPLING REAGENTS
ACETIC-ANHYDRIDE
DECARBOXYLASE INHIBITORS
AMIDE BOND FORMATION
C-N BOND
CLEAVAGE
MOLECULAR-OXYGEN
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ISSN1359-7345
1364-548X
1364-548X
DOI10.1039/C5CC07454A

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Summary:A general and efficient method for the synthesis of tertiary amides has been developed via the copper-catalyzed aerobic oxidative amidation of tertiary amines. Due to the use of the O 2 oxidant, various functional groups were well tolerated under the present conditions. Extensive substrates studies demonstrated its potential as a practical approach for the synthesis of tertiary amides.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/C5CC07454A