Health Care-Associated Infections in a Neurocritical Care Unit of a Developing Country

• Published in: Neurocritical care Vol. 32; no. 3; pp. 836 - 846
• Main Authors: Abulhasan, Yasser B., Abdullah, Aneesa A., Shetty, Shama A., Ramadan, Moustapha A., Yousef, Waleed, Mokaddas, Eiman M.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2020; Springer Nature B.V
• Subjects: Adult; Bacteremia - epidemiology; Catheter-Related Infections - epidemiology; Central Venous Catheters; Critical Care Medicine; Cross Infection - epidemiology; Developing Countries; Disease control; Disease prevention; Female; Healthcare-Associated Pneumonia - epidemiology; Hospital Mortality; Hospital Units; Hospitals, Teaching; Humans; Incidence; Intensive; Intensive Care Units; Internal Medicine; Kuwait - epidemiology; LDCs; Length of Stay - statistics & numerical data; Male; Medicine; Medicine & Public Health; Middle Aged; Mortality; Nervous System Diseases; Neurology; Original Work; Pneumonia, Ventilator-Associated - epidemiology; Proportional Hazards Models; Tertiary Care Centers; Urinary Catheters; Urinary Tract Infections - epidemiology; Ventriculostomy; Kuwait; France; United States > US; Critical care; Ventriculostomy-associated infections; Urinary tract infections; Pneumonia; Ventilator-associated pneumonia; Nosocomial infections
• ISSN: 1541-6933; 1556-0961
• DOI: 10.1007/s12028-019-00856-8

Background Health care-associated infections (HAIs) in intensive care units (ICUs) specialized for neurocritical care (neurocritical care units [NCCUs]) are serious yet preventable complications that contribute significantly to morbidity and mortality worldwide. However, reliable data are scarcely available from the developing world. We aimed to analyze the incidence, epidemiology, microbial etiology, and outcomes of HAIs in an NCCU of a tertiary care teaching hospital in a high-income, developing country. Methods In this 3-year retrospective cohort study, all patients admitted to the NCCU at the Ibn Sina Hospital in Kuwait for ≥ 2 calendar days were included. Patient demographics, hospitalization, and details of ICU-acquired infections were evaluated. Patient-related outcomes included hospital and ICU length of stay (LOS) and in-hospital mortality. Results Among 913 patients with a total of 4921 ICU days, 79 patients had 109 episodes of HAIs. The overall incidence rate and incidence density of HAIs were 11.9/100 patients and 22.1/1000 ICU days, respectively. Multiple episodes of infection were documented in 29% of patients. The most prevalent infections were urinary tract infections (UTIs; 40/109 [37%]), bloodstream infections (30/109 [28%]), and pneumonia (16/109 [15%]). Seventy-six percent of infections were device-associated infections. A total of 158 pathogens were isolated, of which 109 were Gram-negative bacteria. Of the 40 Gram-positive bacteria, 22 were staphylococci. Seven infections were due to Clostridium difficile . There were 15 Staphylococcus aureus isolates, 47% of which were methicillin resistant. Two episodes of UTIs were due to Candida species. There were 84 Enterobacteriaceae isolates, 24% of which were extended-spectrum β-lactamase producers. All Pseudomonas aeruginosa isolates were susceptible to aminoglycosides and carbapenems. Klebsiella species were the most common pathogen (45/158 [28%]), causing pneumonia (11/33 isolates [33%]), bloodstream infections (12/37 isolates [32%]), and UTIs (16/52 isolates [31%]). One episode of bloodstream infection was due to multidrug resistant Acinetobacter baumanii which was susceptible only to colistin. Only pneumonia was independently associated with mortality, while all HAIs that occurred were significantly associated with a prolonged ICU LOS. Conclusions This is the first HAI surveillance study in an NCCU in Kuwait, and our results demonstrate the burden of HAIs on the neurologically injured patient, regardless of the site of infection. The high prevalence and resistant profile of HAIs in an NCCU in a developing country relative to a developed country has important implications for patient safety and emphasizes the need to strengthen collaboration between NCCU teams and infection control teams to prevent serious complications in this setting.