Inactivated Marburg virus elicits a nonprotective immune response in Rhesus monkeys

• Published in: Journal of biotechnology Vol. 44; no. 1; pp. 111 - 118
• Main Authors: Ignatyev, George M., Agafonov, Alexander P., Streltsova, Marina A., Kashentseva, Elena A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 26.01.1996
• Subjects: AIDS/HIV; Animals; Antibodies, Viral - biosynthesis; Antibodies, Viral - blood; Antibody Formation; Biotechnology; CD4-CD8 Ratio; Guinea Pigs; Immune response; Interferons - biosynthesis; Killer Cells, Natural - immunology; Kinetics; Lymphocyte Activation; Lymphocyte proliferation; Macaca mulatta; Marburg virus; Marburg Virus Disease - immunology; Marburg Virus Disease - prevention & control; Marburgvirus - immunology; Mediator of immunity; Time Factors; Tumor Necrosis Factor-alpha - biosynthesis; Vaccines, Inactivated; Viral Vaccines; Virus antibody; Lymphocyte proliferation; Mediator of immunity; Immune response; Marburg virus; Virus antibody
• ISSN: 0168-1656; 1873-4863
• DOI: 10.1016/0168-1656(95)00104-2

In the present work the kinetics of some indices of immunity (tumor necrosis factor (TNF), interferon (IFN), natural killer cells (NK), lymphocyte proliferation activity, virus-specific antibodies, CD4/CD8 ratio) in response to Marburg virus infection in Macaca mulatta were studied. The different kinetics of immunological parameters for animals which survived Marburg virus infection and for animals which died after infection are shown. A comparison of the indices of IFN, TNF and spontaneous lymphocyte proliferation activity in Macaca mulatta infected with Marburg virus at different stages of life shows the relationship between the increase of these indices and the decrease in the animals' lifespan. Marburg virus immunosuppressive properties were corroborated by studying lymphocyte proliferation activity in response to antigenic stimulation in vitro and the CD4/CD8 index during experimental Marburg virus infection in Macaca mulatta. We conclude that the disease outcome depends on the dynamics of certain immunologie indices such as TNF and IFN.