Protective effect of curcumin against rotenone-induced substantia nigra pars compacta neuronal dysfunction

Rotenone is involved in the degeneration of dopaminergic neurons, and curcumin may prevent or effectively slow the progression of Parkinson’s disease (PD). Previous research has shown that the naturally occurring phenolic compound curcumin can reduce inflammation and oxidation, making it a potential...

Full description

Saved in:
Bibliographic Details
Published inMetabolic brain disease Vol. 37; no. 4; pp. 1111 - 1118
Main Authors Darbinyan, L. V., Simonyan, K. V., Hambardzumyan, L. E., Manukyan, L. P., Badalyan, S. H., Sarkisian, V. H.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.04.2022
Springer Nature B.V
Subjects
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Chemical compounds
Curcumin
Curcumin - pharmacology
Curcumin - therapeutic use
Degeneration
Dopamine receptors
Dopaminergic Neurons
Male
Metabolic Diseases
Movement disorders
Neurodegeneration
Neurodegenerative diseases
Neurology
Neurons
Neurosciences
Neurotoxicity
Oncology
Original Article
Oxidation
Parkinson Disease - drug therapy
Parkinson's disease
Pars Compacta
Pharmacology
Phenolic compounds
Phenols
Rats
Rodents
Rotenone
Rotenone - toxicity
Substantia Nigra
In vivo electrophysiology
Curcumin
Substantia nigra pars compacta
Rotenone
Online AccessGet full text

Cover

More Information
Summary:Rotenone is involved in the degeneration of dopaminergic neurons, and curcumin may prevent or effectively slow the progression of Parkinson’s disease (PD). Previous research has shown that the naturally occurring phenolic compound curcumin can reduce inflammation and oxidation, making it a potential therapeutic agent for neurodegenerative diseases. The present study involves investigation of rotenone-induced histological changes in the brain area, hippocampus using Nissl staining after 35 day of subcutaneous injection of rotenone in adult male rats. We sought to determine whether curcumin could protect against rotenone-induced dopaminergic neurotoxicity in a rat model by in vivo electrical recording from Substantia nigra pars compacta (SNc). Curcumin treatment significantly improved electrical activity of neurons in the SNc of rotenone-induced PD model rats. The pattern of histological alterations corresponds with electrophysiological manifestations.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-022-00941-6