Examination of stress-related genes in human temporal versus occipital cortex in the course of neurodegeneration: involvement of 14-3-3 zeta in this dynamic process

• Published in: Neuroscience letters Vol. 365; no. 1; pp. 1 - 5
• Main Authors: Soulié, Cathia, Nicole, Annie, Delacourte, André, Ceballos-Picot, Irène
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 15.07.2004; Elsevier
• Subjects: 14-3-3 Proteins; 14-3-3 zeta; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer’s disease; Biological and medical sciences; Brain - pathology; Brain - physiology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Fundamental and applied biological sciences. Psychology; Gene Expression; Gene Expression Profiling; Human brain; Humans; Male; Medical sciences; Middle Aged; Nerve Degeneration - pathology; Neurodegeneration; Neurofibrillary Tangles - genetics; Neurology; Occipital Lobe - pathology; Occipital Lobe - physiology; Reverse Transcriptase Polymerase Chain Reaction; Stress, Physiological - genetics; Temporal Lobe - pathology; Temporal Lobe - physiology; Tyrosine 3-Monooxygenase - genetics; Vertebrates: nervous system and sense organs; Human brain; Aging; 14-3-3 zeta; Alzheimer’s disease; Neurodegeneration; Human; Nervous system diseases; Senescence; Alzheimer disease; Central nervous system; Temporal cortex; Stress; Cerebral disorder; Occipital cortex; Central nervous system disease; Degenerative disease; Degeneration; Alzheimer's disease
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2004.03.090

The progressive invasion of the brain by neurofibrillary tangles characterized by paired helical filaments (PHF) along a precise network is stereotypical and hierarchical from normal aging to severe Alzheimer’s disease. We describe here the differential expression of genes in the temporal area with PHF compared with the occipital area non-affected by PHF in cases with cognitive impairment versus the same cortical regions of control human brains without PHF. A stronger overexpression for 14-3-3 zeta gene is demonstrated in the affected temporal cortex of cases with cognitive impairment than in cases with normal mental status. This data obtained directly from human brains confirmed a 14-3-3 zeta implication in the Alzheimer’s neuropathology.