Rh-Catalyzed oxidative C–H activation/annulation: converting anilines to indoles using molecular oxygen as the sole oxidant

• Published in: Chemical communications (Cambridge, England) Vol. 50; no. 33; pp. 4331 - 4334
• Main Authors: Zhang, Guoying, Yu, Hui, Qin, Guiping, Huang, Hanmin
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 01.01.2014
• Subjects: Activation; Alkynes; Aniline; carbon-hydrogen bond activation; catalytic activity; chemical reactions; Chemistry; Chemistry, Multidisciplinary; Indoles; Oxidants; Oxidizing agents; Oxygen; Physical Sciences; rhodium; Science & Technology; Sole; FUNCTIONALIZATION; HAPALINDOLES; ACETANILIDES; ACTIVATION; AMINATION; ANNULATION; EFFICIENT SYNTHESIS; POTASSIUM; BOND; CYCLIZATION

A practical and efficient Rh( iii )-catalyzed aerobic C–H activation has been developed for the facile synthesis of a broad range of indoles from simple anilines and alkynes. The protocol could be conducted under mild conditions and used environmentally friendly oxygen as the sole clear oxidant.