Rh-Catalyzed oxidative C–H activation/annulation: converting anilines to indoles using molecular oxygen as the sole oxidant

A practical and efficient Rh( iii )-catalyzed aerobic C–H activation has been developed for the facile synthesis of a broad range of indoles from simple anilines and alkynes. The protocol could be conducted under mild conditions and used environmentally friendly oxygen as the sole clear oxidant.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 50; no. 33; pp. 4331 - 4334
Main Authors Zhang, Guoying, Yu, Hui, Qin, Guiping, Huang, Hanmin
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2014
Subjects
Activation
Alkynes
Aniline
carbon-hydrogen bond activation
catalytic activity
chemical reactions
Chemistry
Chemistry, Multidisciplinary
Indoles
Oxidants
Oxidizing agents
Oxygen
Physical Sciences
rhodium
Science & Technology
Sole
FUNCTIONALIZATION
HAPALINDOLES
ACETANILIDES
ACTIVATION
AMINATION
ANNULATION
EFFICIENT SYNTHESIS
POTASSIUM
BOND
CYCLIZATION
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Summary:A practical and efficient Rh( iii )-catalyzed aerobic C–H activation has been developed for the facile synthesis of a broad range of indoles from simple anilines and alkynes. The protocol could be conducted under mild conditions and used environmentally friendly oxygen as the sole clear oxidant.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/C3CC49751H