Mutations at the asp locus of Drosophila lead to multiple free centrosomes in syncytial embryos, but restrict centrosome duplication in larval neuroblasts

• Published in: Journal of cell science Vol. 96; no. 4; pp. 605 - 616
• Main Authors: GONZALEZ, C, SAUNDERS, R. D. C, CASAL, J, MOLINA, I, CARMENA, M, RIPOLL, P, GLOVER, D. M
• Format: Journal Article
• Language: English
• Published: Cambridge Company of Biologists 01.08.1990
• Subjects: Alleles; Animals; Biological and medical sciences; Brain - embryology; Diptera; Drosophila; Drosophilidae; Embryo, Nonmammalian; Female; Fluorescent Antibody Technique; Fundamental and applied biological sciences. Psychology; Male; Meiosis - genetics; Microtubules; Mitosis - genetics; Molecular and cellular biology; Molecular genetics; Mutagenesis. Repair; Mutation; Nondisjunction, Genetic; Spindle Apparatus; Testis - embryology; Embryonic development; Microscopy; Arthropoda; Insecta; Cell cycle; Mutation; Invertebrata; Drosophila melanogaster; Diptera; Drosophilidae

Mutations at abnormal spindle result in abnormally long and wavy microtubules in the meiotic spindles of males. Some of these spindles have a single pole and take the form of unopposed hemi-spindles. Unfertilised eggs produced by homozygous asp females may have either no nuclei, or a small number of...