Eu(III) complex based on nonsteroidal anti-inflammatory drugs loxoprofen as the ligand: A novel low-toxic luminescent material for cell imaging

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 229; p. 118014
• Main Authors: Dong, Yu, Suo, Hao, Yang, Xing, Zhao, Xiaoqi, Zhou, Xianju
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 15.03.2020
• Subjects: Bio-imaging; Lanthanide complex; Low toxicity; Loxoprofen; Lanthanide complex; Low toxicity; Loxoprofen; Bio-imaging
• ISSN: 1386-1425; 1873-3557
• DOI: 10.1016/j.saa.2019.118014

Eu(III) 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid complex (Eu-LPF), a novel low-toxic luminescent material based on energy transfer between the LPF ligand and Eu3+ ion, was synthesized and characterized by means of elemental analysis, thermogravimetric analyses, and FT-IR spectra. The spectroscopic properties of Eu-LPF were studied using UV–vis absorption spectroscopy and steady/transient state luminescence spectroscopy. Furthermore, the cytotoxicity of Eu-LPF on MCF-7 cells was investigated by MTT assay and flow cytometry. Its biocompatibility and utilization for cell imaging were studied as well. The results showed that Eu-LPF exhibited favorable luminescence properties, low toxicity and good biocompatibility, which endowed Eu-LPF with a potential capability for bioimaging and optical detection. A novel low-toxic red emission Eu-loxoprofen complex was synthesized, which had a potential application in bioimaging and optical detection. [Display omitted] •Eu(III)-loxoprofen complex (Eu-LPF) was synthesized using chemical precipitation method.•Eu-LPF exhibited bright red luminescence at around 616 nm via exciting the LPF ligand.•Eu-LPF was of good biocompatibility and exhibited the potential capability for bio-imaging.