Periradicular inflammatory response, bone resorption, and cementum repair after sealing of furcation perforation with mineral trioxide aggregate (MTA Angelus™) or Biodentine

• Published in: Clinical oral investigations Vol. 23; no. 11; pp. 4019 - 4027
• Main Authors: de Sousa Reis, Magda, Scarparo, Roberta Kochenborger, Steier, Liviu, de Figueiredo, José Antônio Poli
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2019; Springer Nature B.V
• Subjects: Aluminum Compounds; Animals; Bone Resorption; Calcium Compounds; Cementum; Dental Cementum; Dentistry; Drug Combinations; Inflammation; Male; Mandible; Medicine; Molars; Original Article; Oxides; Rats; Rats, Wistar; Rodents; Silicates; Teeth; Furcation perforation; Biodentine; Mineral trioxide aggregate; Repair
• ISSN: 1432-6981; 1436-3771
• DOI: 10.1007/s00784-019-02833-z

Objective This study assessed tissue responses after furcation perforation and immediate sealing with either Biodentine™ or MTA Angelus™. Material and methods Sixty male Wistar rats were used ( n  = 6 per group/period). The mandibular first molars had the furcation mechanically exposed and sealed with either MTA or Biodentine™ and restored with silver amalgam. In an additional test group, teeth were sealed only with Biodentine™. Furcation sealing with gutta-percha and silver amalgam restoration served as positive control, and healthy untreated teeth were the negative control. Histological evaluation was performed after 14 or 21 days. Kruskal-Wallis and Dunn’s post hoc tests were performed to analyze the extent and intensity of tissue inflammation, bone resorption, and cementum repair ( p  < 0.05). Results Biodentine™ and MTA presented satisfactory results, showing a milder inflammatory response when compared to the control, regardless of the material used for coronal sealing and of the experimental period evaluated ( p  < 0.0001). All test groups showed less bone resorption than the positive control after 21 days ( p  < 0.05), and such differences were more pronounced in teeth restored with silver amalgam. Cementum repair was performed in 30% of MTA and Biodentine™ samples but not carried out in any positive control specimen. Conclusions Biodentine™ and MTA promoted similar responses when used to seal furcation perforations and should therefore be regarded as a promising alternative. Clinical relevance Knowledge about tissue responses to restorative materials is essential for improving root perforation sealing protocols. The present results showed that both Biodentine™ and MTA promoted appropriate periradicular tissue reactions in a preclinical test for evaluating furcation perforation treatments.