A ratiometric fluorescent probe for in situ quantification of basal mitochondrial hypochlorite in cancer cells

A ratiometric fluorescent probe ( RMClO-2 ) for ClO − based on the conjugate of coumarin–rhodamine was presented, which could sense ClO − with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, RMClO-2 is the first mitochondria-targeted ratiometric fluorescent...

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Published inChemical communications (Cambridge, England) Vol. 51; no. 31; pp. 6781 - 6784
Main Authors Hou, Ji-Ting, Li, Kun, Yang, Jin, Yu, Kang-Kang, Liao, Ye-Xin, Ran, Yu-Zhao, Liu, Yan-Hong, Zhou, Xue-Dong, Yu, Xiao-Qi
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.04.2015
Subjects
Animals
Cancer
Cell Line
chemical reactions
Chemistry
Chemistry, Multidisciplinary
Conjugates
Coumarins - chemistry
Fluorescence
fluorescent dyes
Fluorescent Dyes - chemistry
Humans
hypochlorites
Hypochlorous Acid - chemistry
Hypochlorous Acid - metabolism
image analysis
Mice
mitochondria
Mitochondria - metabolism
neoplasm cells
neoplasms
Physical Sciences
Rhodamines - chemistry
Science & Technology
Selectivity
Sensitivity
TURN-ON
ANIMALS
OXIDATIVE STRESS
MYELOPEROXIDASE
ACID
DYES
INFLAMMATION
BODIPY-BASED PROBE
LIVING CELLS
HCLO
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Summary:A ratiometric fluorescent probe ( RMClO-2 ) for ClO − based on the conjugate of coumarin–rhodamine was presented, which could sense ClO − with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, RMClO-2 is the first mitochondria-targeted ratiometric fluorescent probe to image exogenous and endogenous ClO − .
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/C5CC01217A