Prognostic indicators in adult cerebral malaria: a study in Burundi, an area of high prevalence of HIV infection

• Published in: Acta tropica Vol. 56; no. 4; pp. 299 - 305
• Main Authors: Niyongabo, T., Deloron, P., Aubry, P., Ndarugirire, F., Manirakiza, F., Muhirwa, G., Ndayiragije, A., Brelivet, J.C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.1994
• Subjects: Adult; AIDS/HIV; Animals; Bilirubin - blood; Burundi - epidemiology; Cerebral malaria; Creatinine - blood; Female; Glasgow Coma Scale; HIV Antibodies - blood; HIV Infections - complications; HIV Infections - epidemiology; HIV-1; HIV-1 - immunology; Humans; Infusions, Intravenous; Liver Diseases - etiology; Liver Diseases - mortality; Malaria; Malaria, Cerebral - complications; Malaria, Cerebral - epidemiology; Malaria, Cerebral - mortality; Malaria, Cerebral - physiopathology; Male; Plasmodium falciparum; Plasmodium falciparum - isolation & purification; Population; Prevalence; Prognosis; Quinine - administration & dosage; Renal Insufficiency - etiology; Renal Insufficiency - mortality; Risk Factors; Burundi; Cerebral malaria; HIV-1; Plasmodium falciparum; Malaria; Measurement; Burundi; Eastern Africa; Prevalence; Viral Diseases; Biology; Hematologic Tests; Laboratory Procedures; Research Methodology; Clinical Research; Research Report; Physiology; Parasitic Diseases; Laboratory Examinations And Diagnoses; Central Nervous System Effects; Africa; French Speaking Africa; Hiv Infections; Examinations And Diagnoses; Diseases; Screening; Central Nervous System; Developing Countries; Africa South Of The Sahara
• ISSN: 0001-706X; 1873-6254
• DOI: 10.1016/0001-706X(94)90101-5

We examined the possible risk factors for poor prognostic in cerebral malaria in 31 adults from Burundi, an area of high prevalence rate of HIV-1 infection. Depth of coma, temperature, vomiting, seizures, parasite load, or anaemia did not modify the outcome. High levels of creatinine, bilirubin, and/or lactates were indicators of poor prognostic. HIV-1 infection did not affect the clinical or biological presentation of cerebral malaria, and did not appear to influence the outcome.