Function and Mechanism of Abscisic Acid on Microglia-Induced Neuroinflammation in Parkinson's Disease

• Published in: International journal of molecular sciences Vol. 25; no. 9; p. 4920
• Main Authors: Han, Tingting, Xu, Yuxiang, Liu, Haixuan, Sun, Lin, Cheng, Xiangshu, Shen, Ying, Wei, Jianshe
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2024
• Subjects: Abscisic acid; Abscisic Acid - metabolism; Abscisic Acid - pharmacology; Animals; B cells; Biological products; Brain research; Chemokines; Cytokines; Disease; Homeostasis; Humans; Inflammation; Microglia - drug effects; Microglia - metabolism; microglia polarization; Nervous system; neuroinflammation; Neuroinflammatory Diseases - drug therapy; Neuroinflammatory Diseases - etiology; Neuroinflammatory Diseases - metabolism; Neurons; neuroprotection; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Neurotoxicity; Parkinson Disease - drug therapy; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson’s disease; Pathogenesis; Pathogens; Physiology; Proteins; Seeds; signal pathway; Tumor necrosis factor-TNF; abscisic acid; signal pathway; neuroinflammation; neuroprotection; Parkinson’s disease; microglia polarization
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25094920

Parkinson's disease (PD), as a neurologically implemented disease with complex etiological factors, has a complex and variable pathogenesis. Accompanying further research, neuroinflammation has been found to be one of the possible factors in its pathogenesis. Microglia, as intrinsic immune cells in the brain, play an important role in maintaining microenvironmental homeostasis in the brain. However, over-activation of neurotoxic microglia in PD promotes neuroinflammation, which further increases dopaminergic (DA) neuronal damage and exacerbates the disease process. Therefore, targeting and regulating the functional state of microglia is expected to be a potential avenue for PD treatment. In addition, plant extracts have shown great potential in the treatment of neurodegenerative disorders due to their abundant resources, mild effects, and the presence of multiple active ingredients. However, it is worth noting that some natural products have certain toxic side effects, so it is necessary to pay attention to distinguish medicinal ingredients and usage and dosage when using to avoid aggravating the progression of diseases. In this review, the roles of microglia with different functional states in PD and the related pathways inducing microglia to transform into neuroprotective states are described. At the same time, it is discussed that abscisic acid (ABA) may regulate the polarization of microglia by targeting them, promote their transformation into neuroprotective state, reduce the neuroinflammatory response in PD, and provide a new idea for the treatment of PD and the selection of drugs.