Hepatitis C virus infection and risk of thyroid cancer: A systematic review and meta-analysis

Several epidemiological studies investigated the relationship between hepatitis C virus (HCV) infection and risk of thyroid cancer, but the results were not consistent. A systematic review and meta-analysis was conducted to assess the impact of HCV infection on thyroid cancer risk. The literature wa...

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Published inArab journal of gastroenterology Vol. 18; no. 1; pp. 1 - 5
Main Authors Wang, Peng, Jing, Zhaohai, Liu, Changjiang, Xu, Meihua, Wang, Pei, Wang, Xiao, Yin, Yulei, Cui, Ying, Ren, Dunlin, Rao, Xiaopang
Format Journal Article
LanguageEnglish
Published Egypt Elsevier B.V 01.03.2017
Subjects
Global Health
Hepacivirus
Hepatitic C virus
Hepatitis C - complications
Hepatitis C - diagnosis
Hepatitis C - virology
Humans
Incidence
Meta-analysis
Risk Factors
Thyroid cancer
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - epidemiology
Thyroid Neoplasms - etiology
RR
NOS
Thyroid cancer
CI
HCV
Hepatitic C virus
Meta-analysis
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Summary:Several epidemiological studies investigated the relationship between hepatitis C virus (HCV) infection and risk of thyroid cancer, but the results were not consistent. A systematic review and meta-analysis was conducted to assess the impact of HCV infection on thyroid cancer risk. The literature was searched up to March 15, 2016 for case-control or cohort studies on the association between HCV infection and thyroid cancer risk. The summary relative risks (RR) and 95% confidence intervals (CI) were calculated. Five studies (two case-control studies and three cohort studies) were included in the meta-analysis, with a total of 751,551 participants and 367 cases of thyroid cancer. Meta-analysis of those 5 studies found that there was no statistically significant association between HCV infection and thyroid cancer risk (summary RR=2.09, 95%CI 0.78–5.64, p=0.145; I2=81.2%). However, HCV infection was significantly associated with increased risk of thyroid cancer (summary RR=2.86, 95%CI 1.63–5.03, p=0.003; I2=24.9%) after adjusting the heterogeneity. There is a possible association between HCV infection and increased risk of thyroid cancer, and more cohort studies are needed to validate the possible association.
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ISSN:1687-1979
2090-2387
DOI:10.1016/j.ajg.2017.01.003