Sumoylation: a regulatory protein modification in health and disease

• Published in: Annual review of biochemistry Vol. 82; p. 357
• Main Authors: Flotho, Annette, Melchior, Frauke
• Format: Journal Article
• Language: English
• Published: United States 01.01.2013
• Subjects: Animals; Genetic Predisposition to Disease; Humans; Proteins - metabolism; Signal Transduction - genetics; Signal Transduction - physiology; Small Ubiquitin-Related Modifier Proteins - metabolism; Sumoylation

Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds of proteins involved in processes such as chromatin organization, transcription, DNA repair, macromolecular assembl...