Sumoylation: a regulatory protein modification in health and disease

Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds of proteins involved in processes such as chromatin organization, transcription, DNA repair, macromolecular assembl...

Full description

Saved in:
Bibliographic Details
Published inAnnual review of biochemistry Vol. 82; p. 357
Main Authors Flotho, Annette, Melchior, Frauke
Format Journal Article
LanguageEnglish
Published United States 01.01.2013
Subjects
Animals
Genetic Predisposition to Disease
Humans
Proteins - metabolism
Signal Transduction - genetics
Signal Transduction - physiology
Small Ubiquitin-Related Modifier Proteins - metabolism
Sumoylation
Online AccessGet more information

Cover

More Information
Summary:Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds of proteins involved in processes such as chromatin organization, transcription, DNA repair, macromolecular assembly, protein homeostasis, trafficking, and signal transduction are subject to reversible sumoylation. Hence, it is not surprising that disease links are beginning to emerge and that interference with sumoylation is being considered for intervention. Here, we summarize basic mechanisms and highlight recent developments in the physiology of sumoylation.
ISSN:1545-4509
DOI:10.1146/annurev-biochem-061909-093311