Certainty of S100 from Physiology to Pathology

S100 exists in wide variety of tissues and cell types, originally isolated from brain tissue and they are of low molecular weight proteins. S100 is evenly distributed in cytoplasm and also in nucleoplasm and is involved in both intercellular and extracellular functions. S100 protein is generally exp...

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Published inJournal of clinical and diagnostic research Vol. 10; no. 6; pp. ZE10 - ZE15
Main Authors Kuberappa, Puneeth Horatti, Bagalad, Bhavana Shivanand, Ananthaneni, Anuradha, Kiresur, Md Asif, Srinivas, Guduru Vijay
Format Journal Article
LanguageEnglish
Published India JCDR Research and Publications Private Limited 01.06.2016
Subjects
odontogenic cyst and tumor
oral squamous cell carcinoma
soft tissue tumors
Soft tissue tumors
Odontogenic cyst and tumor
Oral squamous cell carcinoma
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Summary:S100 exists in wide variety of tissues and cell types, originally isolated from brain tissue and they are of low molecular weight proteins. S100 is evenly distributed in cytoplasm and also in nucleoplasm and is involved in both intercellular and extracellular functions. S100 protein is generally expressed in normal and also in pathological conditions. In current review, we discuss: a) update nomenclature of the various S100 proteins, b) expression of S100 in oral diseases (different soft tissue tumors, odontogenic cyst and tumor) for diagnostic value and also to know their histogenesis, c) role of S100 and RAGE receptor in oral squamous cell carcinoma.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2016/17949.8022