Effects of fucoidan on chronic renal failure in rats

The effects of fucoidan on chronic renal failure (CRF) were investigated in vivo in a subtotal nephrectomy CRF model and a cryoinjury induced CRF model in rats. Fucoidan showed renoprotective effects in both models. Fucoidan (100 or 200 mg/kg, orally) significantly decreased elevated serum creatinin...

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Published inPlanta medica Vol. 69; no. 6; p. 537
Main Authors Zhang, Quanbin, Li, Zhien, Xu, Zuhong, Niu, Xizhen, Zhang, Hong
Format Journal Article
LanguageEnglish
Published Germany 01.06.2003
Subjects
Administration, Oral
Animals
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Blood Flow Velocity
Blood Urea Nitrogen
Disease Models, Animal
Dogs
Dose-Response Relationship, Drug
Kidney - blood supply
Kidney - drug effects
Kidney - injuries
Kidney Failure, Chronic - prevention & control
Laminaria
Male
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Polysaccharides - administration & dosage
Polysaccharides - pharmacology
Polysaccharides - therapeutic use
Rats
Rats, Wistar
Renal Artery - physiology
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Summary:The effects of fucoidan on chronic renal failure (CRF) were investigated in vivo in a subtotal nephrectomy CRF model and a cryoinjury induced CRF model in rats. Fucoidan showed renoprotective effects in both models. Fucoidan (100 or 200 mg/kg, orally) significantly decreased elevated serum creatinine and urea nitrogen levels. Histopathological changes of renal tubules and interstitium were markedly alleviated by fucoidan and the mesangial areas were also greatly reduced. The activities of fucoidan were dose-dependent.
ISSN:0032-0943
DOI:10.1055/s-2003-40634