Saline-pocket endoscopic submucosal dissection for superficial colorectal neoplasms: a randomized controlled trial (with video)

• Published in: Gastrointestinal endoscopy Vol. 90; no. 2; pp. 278 - 287
• Main Authors: Harada, Hideaki, Nakahara, Ryotaro, Murakami, Daisuke, Suehiro, Satoshi, Ujihara, Tetsuro, Sagami, Ryota, Katsuyama, Yasushi, Hayasaka, Kenji, Amano, Yuji
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2019
• Subjects: Aged; Aged, 80 and over; Colorectal Neoplasms - pathology; Colorectal Neoplasms - surgery; Dissection - methods; Endoscopic Mucosal Resection - methods; Female; Humans; Male; Middle Aged; Prospective Studies; Saline Solution - administration & dosage; LST-NG; LST-G; ESD; SP-ESD; S-ESD; LST; SCN
• ISSN: 0016-5107; 1097-6779
• DOI: 10.1016/j.gie.2019.03.023

Colorectal endoscopic submucosal dissection (ESD) is a time-consuming procedure because of the technical difficulty. The newly developed saline-pocket ESD (SP-ESD) provides a clearer view and better traction of the submucosal layer compared with the standard ESD with gas insufflation (S-ESD). This study aimed to prospectively compare the efficacy and safety between S-ESD and SP-ESD in patients with superficial colorectal neoplasms (SCNs). From April 2017 to November 2018, 95 patients with SCNs ≥20 mm in diameter were prospectively and randomly enrolled. Four patients were excluded because of an incomplete ESD procedure. Patients were finally allocated to 2 groups, S-ESD with 45 patients and SP-ESD with 46 patients. The primary outcome was dissection speed. Secondary outcomes were ESD procedure time, en bloc and complete resection rates, perforation rate, and adverse effects. Median dissection speed was significantly faster in the SP-ESD than the S-ESD group (20.1 mm2/min [range, 17.3-28.1] vs 16.3 mm2/min [range, 11.4-19.8]; P < .001). Median procedure time was significantly shorter in the SP-ESD than the S-ESD group (29.5 minutes [range, 22.3-44] vs 41 minutes [range, 31-55]; P < .001). The en bloc and complete resection rates were 100% in both groups. No perforations occurred among patients. The volume of saline solution used in the SP-ESD group was significantly greater than that in the S-ESD group (200 mL [range, 120-250] vs 150 mL [range, 100-200]; P = .016). SP-ESD improved dissection speed and procedure time compared with S-ESD. SP-ESD may be an alternative method for resection of SCNs. (Clinical trial registration number: UMIN 000026317.) [Display omitted]