An electrochemiluminescence biosensor for Kras mutations based on locked nucleic acid functionalized DNA walkers and hyperbranched rolling circle amplification

Herein, an electrochemiluminescence (ECL) biosensor for ultrasensitive and specific detection of Kras mutant genes has been developed on the basis of the high discrimination capability of locked nucleic acid (LNA) and dual signal amplification techniques including DNA walkers and hyperbranched rolli...

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Published inChemical communications (Cambridge, England) Vol. 53; no. 20; pp. 2910 - 2913
Main Authors Zhang, Ying, Wang, Lixu, Luo, Fang, Qiu, Bin, Guo, Longhua, Weng, Zuquan, Lin, Zhenyu, Chen, Guonan
Format Journal Article
LanguageEnglish
Published England 2017
Subjects
Amplification
Biosensing Techniques
Biosensors
Deoxyribonucleic acid
Discrimination
DNA - genetics
DNA Replication
Electrochemical Techniques
Electrochemiluminescence
Genes
Humans
Luminescent Measurements
Mutation
Mutations
Nucleic Acid Amplification Techniques
Nucleic acids
Oligonucleotides - genetics
Proto-Oncogene Proteins p21(ras) - genetics
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Summary:Herein, an electrochemiluminescence (ECL) biosensor for ultrasensitive and specific detection of Kras mutant genes has been developed on the basis of the high discrimination capability of locked nucleic acid (LNA) and dual signal amplification techniques including DNA walkers and hyperbranched rolling circle amplification (HRCA).
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ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc00009j