Cholesterol-lowering in hamsters fed rice bran at various levels, defatted rice bran and rice bran oil

• Published in: The Journal of nutrition Vol. 122; no. 3; pp. 513 - 519
• Main Authors: KAHLON, T. S, CHOW, F. I, SAYRE, R. N, BETSCHART, A. A
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Bethesda, MD American Society for Nutritional Sciences 01.03.1992
• Subjects: Animals; Biological and medical sciences; Body Weight; Cholesterol - analysis; Cholesterol - blood; Cholesterol, Dietary - administration & dosage; Cricetinae; Dietary Fiber - administration & dosage; Eating; General and cellular metabolism. Vitamins; Liver - anatomy & histology; Liver - chemistry; Male; Medical sciences; Mesocricetus; Organ Size; Oryza; Pharmacology. Drug treatments; Plant Oils - administration & dosage; Random Allocation; Rice Bran Oil; Triglycerides - analysis; Triglycerides - blood; Rodentia; Plant fiber; Lipids; Metabolism; Cholesterol; Feeding; Vertebrata; Mammalia; Hypercholesterolemia; Diet therapy; Animal; Hamster; Rice bran; Antilipemic agent
• ISSN: 0022-3166; 1541-6100
• DOI: 10.1093/jn/122.3.513

This study was conducted to determine the relative cholesterol-lowering effects of several levels of full-fat rice bran in hamsters. In addition, the separate effects of defatted rice bran and/or crude rice bran oil were investigated at levels equivalent to those present in 43.7% full-fat rice bran. Diets containing 10.9, 21.8, 32.8 or 43.7% full-fat rice bran, 35% defatted rice bran and/or 9% rice bran oil were fed to 4-wk-old male hamsters. All diets contained 10% total dietary fiber, 9% fat and 3.2% nitrogen; hypercholesterolemic diets contained 0.3% cholesterol; two diets were cholesterol-free, i.e., 10% cellulose and 43.7% full-fat rice bran. After 21 d, plasma and liver cholesterol, plasma triglycerides and liver weights were significantly greater in hamsters fed the 10% cellulose diet with 0.3% cholesterol compared with those fed the cholesterol-free cellulose diet. In animals fed cholesterol-free diets, plasma cholesterol values were significantly lower in those fed the 43.7% full-fat rice bran diet than in those fed the cellulose diet. In animals fed cholesterol-containing diets, plasma and liver cholesterol were significantly lower in animals fed the 43.7% full-fat rice bran diet than in those fed the cellulose diet. Plasma cholesterol reductions were significantly correlated to the level of rice bran in the diet. In cholesterol-fed hamsters, total liver cholesterol content was significantly lower in those fed the defatted rice bran diet with rice bran oil compared with those fed the cellulose diet. Full-fat rice bran was the only treatment that significantly lowered both plasma and liver cholesterol.