Effects of Dietary Fiber, Carbohydrate, Lipid and Protein Levels on Serum and Liver Lipids in Rats

• Published in: The Journal of nutrition Vol. 117; no. 4; pp. 650 - 659
• Main Authors: Stewart, Janice R., Fryer, E. Beth, Fryer, Holly C.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.04.1987; American Society for Nutritional Sciences
• Subjects: Animals; Biological and medical sciences; BLOOD COMPOSITION; CARBOHIDRATOS; CARBOHYDRATES; Cholesterol - blood; Cholesterol, HDL - blood; COMPOSICION DE LA SANGRE; COMPOSITION DU SANG; CONTENIDO DE FIBRAS; CORPS GRAS; DIET; diet components; DIETA; Dietary Carbohydrates - administration & dosage; Dietary Carbohydrates - analysis; Dietary Fats - administration & dosage; Dietary Fats - analysis; dietary fiber; Dietary Fiber - administration & dosage; Dietary Fiber - analysis; Dietary Proteins - administration & dosage; Dietary Proteins - analysis; FATS; Feeding. Feeding behavior; FIBRE CONTENT; FOIE; Fundamental and applied biological sciences. Psychology; GLUCIDE; GRASAS; HIGADO; Lipid Metabolism; LIPIDE; LIPIDOS; LIPIDS; LIVER; Liver - metabolism; liver lipids; Male; Minerals - administration & dosage; PROTEINAS; PROTEINE; PROTEINS; RAT; RATA; RATS; Rats, Inbred Strains; REGIME ALIMENTAIRE; Regression Analysis; response-surface regression analyses; RESPONSE-SURFACE REGRESSION ANALYSIS; serum lipids; TENEUR EN FIBRES; Triglycerides - blood; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vitamins - administration & dosage; response-surface regression analyses; liver lipids; diet components; dietary fiber; serum lipids; Proteins; Vertebrata; Mammalia; Rat; Diet; Liver; Rodentia; Lipids; Carbohydrate; Regression analysis; Concentration; Dietary fiber
• ISSN: 0022-3166; 1541-6100
• DOI: 10.1093/jn/117.4.650

Response-surface regression analysis was used to study dietary levels of fiber, carbohydrate, lipid and protein to minimize serum and liver cholesterol and triglyceride levels and maximize serum high-density lipoprotein-cholesterol levels of male weanling rats. Because the dietary components were not statistically independent, they were studied in combinations of three variables. The three-variable combinations were the most useful in locating the desired maximum or minimum lipid responses in terms of the proportions of the dietary components. These analyses indicated that dietary carbohydrate, lipid and protein were better than dietary fiber for predicting the serum and liver lipid response levels. Response-surface contours and three-dimensional piots were developed for each lipid response except serum triglycerides, which were not predictable. The contours and three-dimensional piots were used to help determine those combinations of the diet components that would produce the desired maximum or minimum lipid responses. The statistical analyses indicated that the desired lipid response levels could be attained with a diet consisting of 3–5% neutral detergent bran fiber, 6–10% lipid, 54–55% carbohydrate, 26–30% protein and 4.7% vitamins and minerals.