Myopia prevention and control in children: a systematic review and network meta-analysis
Objectives To analyse and compare the efficacy of different interventions for myopia prevention and control in children. Methods We searched CNKI, VIP, Wan-Fang, CBM, Chinese Clinical Registry, PubMed, The Cochrane Library, Web of Science, Embase and ClinicalTrials.gov from inception to July 2022. W...
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Published in | Eye (London) Vol. 37; no. 16; pp. 3461 - 3469 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.11.2023
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | Objectives
To analyse and compare the efficacy of different interventions for myopia prevention and control in children.
Methods
We searched CNKI, VIP, Wan-Fang, CBM, Chinese Clinical Registry, PubMed, The Cochrane Library, Web of Science, Embase and ClinicalTrials.gov from inception to July 2022. We selected randomized controlled trials (RCTs) that included interventions to slow myopia progression in children. The main outcomes included mean annual change in axial length (AL) (millimetres/year) and in refraction (R) (dioptres/year).
Results
A total of 80 RCTs (27103 eyes) were included. In comparison with control, orthokeratology (AL, −0.36 [−0.53, −0.20],
P
< 0.05; R, 0.56 [0.34, 0.77],
P
< 0.05), 1%Atropine (AL, −0.39 [−0.65, −0.13],
P
< 0.05; R, 0.54 [0.31, 0.77],
P
< 0.05), 0.01%Atropine + orthokeratology (AL, −0.47 [−0.80, −0.14],
P
< 0.05; R, 0.81 [0.43, 1.20],
P
< 0.05) could significantly slow the progression of myopia; in addition, progressive multi-focal spectacle lenses (PMSL) (0.42, [0.06, 0.79],
P
< 0.05), bifocal soft contact lenses (0.40, [0.03, 0.77],
P
< 0.05), 0.5%Atropine (0.67 [0.25, 1.10],
P
< 0.05), 0.1%Atropine (0.42 [0.15, 0.71],
P
< 0.05), 0.05%Atropine (0.57 [0.28, 0.86],
P
< 0.05), 0.01%Atropine (0.33 [0.15, 0.52],
P
< 0.05), 1%Atropine + bifocal spectacle lenses (BSL) (1.30 [0.54, 2.00],
P
< 0.05), 1%Atropine + PMSL (0.66 [0.23, 1.10],
P
< 0.05), 0.01%Atropine + single vision spectacle lenses (SVSL) (0.70 [0.23, 1.10],
P
< 0.05), 0.01%Atropine + orthokeratology (0.81 [0.43, 1.20],
P
< 0.05), BSL + Massage (0.85 [0.22, 1.50],
P
< 0.05), SVSL + Red light (0.59 [0.06, 0.79],
P
< 0.05) showed significant slowing effect on the increase in R.
Conclusions
This network meta-analysis suggests that the combined measures were most effective in AL and R, followed by Atropine. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 |
ISSN: | 0950-222X 1476-5454 |
DOI: | 10.1038/s41433-023-02534-8 |