Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest

To the Editor: In the BOX trial, Kjaergaard et al. (Oct. 20 issue) 1 found no significant difference in the percentages of patients who died or had severe disability between those who were treated with a high (77 mm Hg) or a low (63 mm Hg) mean arterial blood-pressure target. As discussed by the aut...

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Published inThe New England journal of medicine Vol. 388; no. 3; pp. 284 - 286
Main Authors Chudeau, Nicolas, Guitton, Christophe, Cariou, Alain, Roedl, Kevin, Kluge, Stefan, Kjaergaard, Jesper, Møller, Jacob E., Hassager, Christian
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 19.01.2023
Subjects
Anesthesia
Arterial Pressure
Blood Pressure
Coma
Coma - etiology
Conflicts of interest
Dopamine
Heart Arrest
Hemodynamics
Humans
Intensive care
Patients
Spectrum analysis
Survivors
Denmark
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Summary:To the Editor: In the BOX trial, Kjaergaard et al. (Oct. 20 issue) 1 found no significant difference in the percentages of patients who died or had severe disability between those who were treated with a high (77 mm Hg) or a low (63 mm Hg) mean arterial blood-pressure target. As discussed by the authors, the clinical significance of the mean difference in mean arterial blood pressure between the two groups, at only 10.7 mm Hg, is unclear. In addition, it is possible that the targeted mean arterial pressure was insufficient in patients with impaired cerebral autoregulation. Ameloot et al. reported . . .
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ObjectType-Commentary-2
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc2215179