Prognostic significance of pretreatment 18F‐fluorodeoxyglucose positron emission tomography evaluation using metabolic tumor volume of the primary tumor and lymph nodes in advanced hypopharyngeal cancer

• Published in: Head & neck Vol. 41; no. 3; pp. 739 - 747
• Main Authors: Okazaki, Eiichiro, Kawabe, Joji, Oishi, Masahiro, Hosono, Masako, Higashiyama, Shigeaki, Teranishi, Yuichi, Shiomi, Susumu, Iguchi, Hiroyoshi, Miki, Yukio
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2019
• Subjects: Cancer; concurrent chemo; Head and neck; hypopharyngeal cancer; Lymph nodes; Lymphatic system; metabolic tumor volume; Metabolism; Metastases; Multivariate analysis; PET; Positron emission tomography; Radiation therapy; radiotherapy; Survival; Throat cancer; Tomography; radiotherapy; concurrent chemo; PET; hypopharyngeal cancer; metabolic tumor volume
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.25429

Background The purpose of this study was to retrospectively evaluate the usefulness of pretreatment positron emission tomography (PET) using metabolic tumor volume (MTV) of the primary tumor and lymph nodes in advanced hypopharyngeal cancer. Methods From June 2007 to December 2015, consecutive patients with advanced hypopharyngeal cancer who underwent PET and were treated with definitive radiation therapy were retrospectively reviewed. Results A total of 61 patients were eligible for this study. On multivariate analysis, MTV of the primary tumor (MTV‐T) was significantly related to the local control rate and overall survival (OS) (P = .036 and .012, respectively). In patients with lower MTV‐T, MTV of metastatic lymph nodes (MTV‐N) was significantly related to disease‐specific survival and OS (P = .012 and .017, respectively). Conclusion MTV‐T is a significant predictor in patients with advanced hypopharyngeal cancer, and MTV‐N is also significant in patients with lower MTV‐T.