Effects on the osseointegration of titanium implants incorporating calcium–magnesium: a resonance frequency and histomorphometric analysis in rabbit tibia

• Published in: Clinical oral implants research Vol. 29; no. 7; pp. 785 - 791
• Main Authors: Gehrke, Sergio Alexandre, Maté Sánchez de Val, José Eduardo, Fernández Domínguez, Manuel, Aza Moya, Piedad Nieves, Gómez Moreno, Gerardo, Calvo Guirado, José Luis
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.07.2018
• Subjects: Animals; Blasting; Bone growth; Bone healing; Bone implants; bone–implant contact; Calcium; calcium–magnesium deposition; dental implant; Dental Implantation, Endosseous - instrumentation; Dental Implantation, Endosseous - methods; Dental Implants; Dentistry; Deposition; Frequency analysis; Grit; implant stability; implant surface; Implantation; Magnesium; Morphology; Osseointegration; Osteogenesis; Rabbits; Resonance; Resonance Frequency Analysis; Scanning electron microscopy; Spectrometry; Statistical analysis; Statistical methods; Surface properties; Surgical implants; Tibia; Tibia - anatomy & histology; Tibia - surgery; Titanium; implant stability; calcium-magnesium deposition; bone-implant contact; osseointegration; implant surface; dental implant
• ISSN: 0905-7161; 1600-0501
• DOI: 10.1111/clr.12909

Objective This study assessed the bone formation around titanium surface incorporating the calcium–magnesium (CaMg) deposited by blasted in rabbit tibia bone to determine whether this surface would further enhance bone healing compared with commercially available implant surface. Material and methods The deposition of CaMg on the titanium SLA surface were obtained by blasting formed the experimental group (EX group), while implants with traditional SLA surface were used as control group (CO group), in this study. Fifty cylindrical threaded implants with a length of 8 mm were used (P = 25 per group). Five implants of each group were used to surface characterization by scanning electron microscopy, energy dispersive spectrometry, and optical profilometry. Ten New Zealand white rabbits received 40 implants (n = 20 per group). Resonance frequency analysis was performed three times (0, 4, and 6 weeks). Histomorphometric analysis was performed 4 and 6 weeks after implantation. Statistical significance was set at P < 0.05. Results Blasted CaMg deposition on SLA implant surface displayed almost identical surface morphologies and R(a) values at the micron scale. In comparing the implant stability quotient at the three time points, highly significant statistic differences were found (P < 0.001). Histomorphological analysis showed higher degrees of bone organization in the samples of test implant surfaces at both implantation times. Conclusion Within the limitations of this study, the results indicate that the deposition of CaMg on the SLA titanium surface may be effective in enhancing the osseointegration of moderately rough grit‐blasted implants by increasing the degree of bone–implant contact.