Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease

• Published in: Movement disorders Vol. 34; no. 1; pp. 48 - 57
• Main Authors: Maraki, Maria I., Yannakoulia, Mary, Stamelou, Maria, Stefanis, Leonidas, Xiromerisiou, Georgia, Kosmidis, Mary H., Dardiotis, Efthimios, Hadjigeorgiou, Georgios M., Sakka, Paraskevi, Anastasiou, Costas A., Simopoulou, Eleni, Scarmeas, Nikolaos
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2019
• Subjects: Aged; Aging; Biomarkers - analysis; Cohort Studies; Constipation; Depression - etiology; Diet; Diet, Mediterranean; Dietary intake; elderly; Female; Greece; Humans; Incidence; Male; Mediterranean; Mental depression; Middle Aged; Movement disorders; neurodegeneration; Neurodegenerative diseases; nutrition; Older people; Parkinson Disease - complications; Parkinson Disease - prevention & control; Parkinson's disease; Population studies; prodromal; Prodromal Symptoms; Treatment Adherence and Compliance; Greece; neurodegeneration; Mediterranean; nutrition; prodromal; elderly
• ISSN: 0885-3185; 1531-8257; 1531-8257
• DOI: 10.1002/mds.27489

ABSTRACT Background The International Parkinson and Movement Disorder Society recently introduced a methodology for probability score calculation for prodromal PD. Objectives To assess the probability of prodromal PD in an older population and investigate its possible association with Mediterranean diet adherence. Methods Data from a population‐based cohort study of older adults (HEllenic Longitudinal Investigation of Aging and Diet) in Greece were used. Probability of prodromal PD was calculated according to International Parkinson and Movement Disorder Society research criteria. A detailed food frequency questionnaire was used to evaluate dietary intake and calculate Mediterranean diet adherence score, ranging from 0 to 55, with higher scores indicating higher adherence. Results Median probability of prodromal PD was 1.9%, ranging from 0.2 to 96.7% in 1,731 PD‐free individuals aged ≥ 65 (41% male). Lower probability for prodromal PD (P < 0.001) in the higher Mediterranean diet adherence groups was noted, driven mostly by nonmotor markers of prodromal PD, depression, constipation, urinary dysfunction, and daytime somnolence. Each unit increase in Mediterranean diet score was associated with a 2% decreased probability for prodromal PD (P < 0.001). Compared to participants in the lowest quartile of Mediterranean diet adherence, those in the highest quartile were associated with a ∼21% lower probability for prodromal PD. Conclusions Adherence to the Mediterranean diet is associated with lower probability of prodromal PD in older people. Further studies are needed to elucidate the potential causality of this association, potential relation of the Mediterranean diet to delayed onset or lower incidence of PD, as well as the underlying neurobiological mechanisms. © 2018 International Parkinson and Movement Disorder Society