A novel platinum-iridium, potentially gamma radioactive stent: Evaluation in a porcine model

• Published in: Catheterization and cardiovascular interventions Vol. 51; no. 3; pp. 364 - 368
• Main Authors: Bhargava, Balram, De Scheerder, Ivan, Ping, Qiang Bei, Yanming, Huang, Chan, Rosanna, Soo Kim, Han, Kollum, Marc, Cottin, Yves, Leon, Martin B.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.11.2000; Wiley-Liss
• Subjects: angioplasty; Animals; Biocompatible Materials; Biological and medical sciences; Constriction, Pathologic; Diseases of the cardiovascular system; Gamma Rays; gamma stent; Iridium; Medical sciences; Models, Animal; Platinum; platinum-iridium alloys; Prosthesis Design; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); restenosis; Stents; Swine; Tunica Intima - pathology; Endoprosthesis; Coronary artery; Instrumentation therapy; Instrumental dilatation; Pig; Prevention; Restenosis; Vertebrata; Gamma irradiation; Mammalia; Treatment; Animal; Complication; Artiodactyla; Ungulata
• ISSN: 1522-1946; 1522-726X
• DOI: 10.1002/1522-726X(200011)51:3<364::AID-CCD28>3.0.CO;2-D

In‐stent restenosis (ISR) is a major problem within stented arteries. Surface treatment of stents with platinum and gold were found to have the maximum charge with least neointima formation (NF). This study was designed to evaluate platinum (maximum electrical charge) as a material to make stents to reduce NF. Iridium was added to make an alloy suitable for stent manufacture, with the potential to make the stent radioactive. We implanted the novel platinum‐iridium (PI) stent in 10 porcine coronaries and compared to the Palmaz‐Schatz (PS) stent implanted in 8 coronary arteries. Six weeks after implantation, angiography of the stented vessel was performed before sacrifice. The coronaries were perfusion‐fixed and stained, and vessel parameters were analyzed by computer‐aided histomorphometry. The thrombus formation and the inflammatory response was less in the PI stent (0.04 ± 0.1 vs. 0.24 ± 0.2, P = 0.005; and 1.1 ± 0.5 vs. 2.4 ± 0.3, P < 0.001). The NF from PI‐stented arteries was smaller in size than the PS controls (1.9 ± 0.6 mm2 vs. 2.4 ± 0.4 mm2, P = 0.06). However, PI stents presented with higher recoil than the PS stent (16% vs. 5%, P < 0.001). Platinum‐iridium is a highly biocompatible material with high performance, low inflammatory response with small NF. This stent does not lead to thrombus formation and has the potential (due to the presence of iridium) to be irradiated to form a gamma radioactive stent. Cathet. Cardiovasc. Intervent. 51:364–368, 2000. © 2000 Wiley‐Liss, Inc.