TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-κB activation

• Published in: FEBS letters Vol. 521; no. 1; pp. 165 - 169
• Main Authors: Stilo, Romania, Leonardi, Antonio, Formisano, Luigi, Di Jeso, Bruno, Vito, Pasquale, Liguoro, Domenico
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 19.06.2002
• Subjects: Apoptosis; Caspase recruitment domain; DRAL; Nuclear factor-κB; p53; Protein; DRAL; Caspase recruitment domain; Nuclear factor-κB; Protein; Apoptosis; p53
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/S0014-5793(02)02869-7

Proteins containing the caspase recruiting domain (CARD) have emerged as critical regulators of different signal transduction pathways, including those controlling apoptosis and activation of necrosis factor (NF)-κB transcription factor. TUCAN/CARDINAL is a recently identified CARD-containing protein involved in regulation of caspases and NF-κB activation. We find that TUCAN/CARDINAL associates with DRAL, a p53-responsive gene implicated in induction of apoptosis. We also show that, whereas TUCAN/CARDINAL exerts a suppressive effect on NF-κB activity, expression of DRAL results in enhancement of NF-κB activation. Thus, our observations suggest that DRAL and TUCAN/CARDINAL may participate in a regulatory mechanism that coordinates cellular responses controlled by NF-κB transcription factor.