Macrophage migration inhibitory factor (MIF), enzymatic activity and the inflammatory response

Macrophage migration inhibitory factor represents a key cytokine in human diseases. It plays an important role in both innate and acquired immunity and has been shown to be a key mediator of inflammatory diseases. More recently MIF has been implicated in cancer pathogenesis. Over the decades its str...

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Published inBioFactors (Oxford) Vol. 35; no. 2; pp. 165 - 168
Main Authors Cooke, Gordon, Armstrong, Michelle E., Donnelly, Seamas C.
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2009
Subjects
Animals
cancer
enzyme
Enzyme Activation
Humans
inflammation
Inflammation - genetics
Inflammation - metabolism
Macrophage Migration-Inhibitory Factors - chemistry
Macrophage Migration-Inhibitory Factors - genetics
Macrophage Migration-Inhibitory Factors - metabolism
MIF
Neoplasms - genetics
Neoplasms - metabolism
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Summary:Macrophage migration inhibitory factor represents a key cytokine in human diseases. It plays an important role in both innate and acquired immunity and has been shown to be a key mediator of inflammatory diseases. More recently MIF has been implicated in cancer pathogenesis. Over the decades its structure and functions have been elucidated and this has led to it being further classified as a hormone and an enzyme. It has isomerase enzymatic activity and increasing evidence implicates this activity in inflammatory disease. Consequently, there is increasing interest in developing small molecular weight inhibitors which could target this novel enzymatic activity in disease. © 2009 International Union of Biochemistry and Molecular Biology, Inc.
Bibliography:ark:/67375/WNG-BHV7PVCR-V
ArticleID:BIOF27
istex:EDDE1AA3DC49DEDE014A3CA006E478D2DEF2B330
Tel: +353‐12774930; Fax: +353‐2214927
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0951-6433
1872-8081
DOI:10.1002/biof.27