Spinal malformation − A biochemical analysis using congenital kyphosis rats

Spinal kyphosis involves the vertebrae curving excessively backward, beyond their physiological curvature. Although the normal structure of the spinal vertebrae is extremely important for maintaining posture, the normal function of the thoracic and abdominal organs, and cosmetics, our knowledge conc...

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Published inJournal of cellular biochemistry Vol. 123; no. 3; pp. 501 - 505
Main Authors Shimokawa, Noriaki, Takahashi, Itsuki, Iizuka, Haku
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.03.2022
Subjects
Animals
Biochemical analysis
Cosmetics
DNA microarrays
Kyphosis
Kyphosis - genetics
Kyphosis - pathology
kyphosis model rats
microRNA array
Pathogenesis
Posture - physiology
Rats
spinal malformation
Spine - pathology
Thorax
Vertebrae
spinal malformation
microRNA array
kyphosis model rats
DNA microarrays
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Summary:Spinal kyphosis involves the vertebrae curving excessively backward, beyond their physiological curvature. Although the normal structure of the spinal vertebrae is extremely important for maintaining posture, the normal function of the thoracic and abdominal organs, and cosmetics, our knowledge concerning the pathogenesis of this disease is lacking. Furthermore, the responsible gene has not yet been identified. In this short review, we summarize the current state of kyphosis research and introduce the molecular and cellular mechanisms associated with the pathogenesis of this disease, based on findings obtained using rats that develop kyphosis.
Bibliography:ObjectType-Article-1
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ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.30206