Toxicity of iron oxide nanoparticles: Size and coating effects

• Published in: Journal of biochemical and molecular toxicology Vol. 32; no. 12; pp. e22225 - n/a
• Main Authors: Abakumov, Maxim A., Semkina, Alevtina S., Skorikov, Alexander S., Vishnevskiy, Daniil A., Ivanova, Anna V., Mironova, Elena, Davydova, Galina A., Majouga, Alexander G., Chekhonin, Vladimir P.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2018
• Subjects: Biocompatibility; Bovine serum albumin; Cancer; Coating effects; Coatings; Cytotoxicity; Fibroblasts; Free radicals; Glioblastoma; Glioblastoma cells; iron oxide nanoparticles; Iron oxides; Magnetite; Nanomaterials; Nanoparticles; Nanotechnology; Polyethylene glycol; Serum albumin; Toxicity; Toxicology; toxicity; polyethylene glycol; iron oxide nanoparticles
• ISSN: 1095-6670; 1099-0461; 1099-0461
• DOI: 10.1002/jbt.22225

Toxicological research of novel nanomaterials is a major developmental step of their clinical approval. Since iron oxide magnetic nanoparticles have a great potential in cancer treatment and diagnostics, the investigation of their toxic properties is very topical. In this paper we synthesized bovine serum albumin‐coated iron oxide nanoparticles with different sizes and their polyethylene glycol derivative. To prove high biocompatibility of obtained nanoparticles the number of in vitro toxicological tests on human fibroblasts and U251 glioblastoma cells was performed. It was shown that albumin nanoparticles’ coating provides a stable and biocompatible shell and prevents cytotoxicity of magnetite core. On long exposure times (48 hours), cytotoxicity of iron oxide nanoparticles takes place due to free radical production, but this toxic effect may be neutralized by using polyethylene glycol modification.