Autophagy and senescence: A new insight in selected human diseases

Senescence and autophagy play important roles in homeostasis. Cellular senescence and autophagy commonly cause several degenerative processes, including oxidative stress, DNA damage, telomere shortening, and oncogenic stress; hence, both events are known to be interrelated. Autophagy is well known f...

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Published inJournal of cellular physiology Vol. 234; no. 12; pp. 21485 - 21492
Main Authors Rajendran, Peramaiyan, Alzahrani, Abdullah M, Hanieh, Hamza N, Kumar, Sekar Ashok, Ben Ammar, Rebai, Rengarajan, Thamaraiselavan, Alhoot, Mohammed A
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.12.2019
Subjects
Aging
arthritis
Autophagy
cancer
cardiac diseases
Cell death
Degeneration
DNA damage
Homeostasis
Neurodegeneration
Neurodegenerative diseases
Oxidative stress
Phagocytosis
renal diseases
Senescence
senescence
renal diseases
cardiac diseases
cancer
autophagy
arthritis
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Summary:Senescence and autophagy play important roles in homeostasis. Cellular senescence and autophagy commonly cause several degenerative processes, including oxidative stress, DNA damage, telomere shortening, and oncogenic stress; hence, both events are known to be interrelated. Autophagy is well known for its disruptive effect on human diseases, and it is currently proposed to have a direct effect on triggering senescence and quiescence. However, it is yet to be proven whether autophagy has a positive or negative impact on senescence. It is known that elevated levels of autophagy induce cell death, whereas inadequate autophagy can trigger cellular senescence. Both have important roles in human diseases such as aging, renal degeneration, neurodegenerative disorders, and cancer. Therefore, this review aims to highlight the relevance of senescence and autophagy in selected human ailments through a summary of recent findings on the connection and effects of autophagy and senescence in these diseases. Crosstalk between autophagy and senescence.
Bibliography:Peramaiyan Rajendran and Abdullah M Alzahrani contributed equally to this work.
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ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.28895