Primary uterine rhabdomyosarcoma in a patient with a history of breast cancer and gastrointestinal stromal tumor

• Published in: The journal of obstetrics and gynaecology research Vol. 34; no. 4pt2; pp. 721 - 725
• Main Authors: Gottwald, Leszek, Gora, Ewa, Korczynski, Jerzy, Piekarski, Janusz H., Morawiec, Zbigniew, Jesionek‐Kupnicka, Dorota, Sowa, Piotr, Cialkowska‐Rysz, Aleksandra, Bienkiewicz, Andrzej
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.08.2008
• Subjects: Aged; anastrozole; Breast - pathology; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Carcinoma, Ductal, Breast - drug therapy; Carcinoma, Ductal, Breast - pathology; embryonal; Female; Gastrointestinal Stromal Tumors - pathology; Humans; Neoplasms, Second Primary - pathology; Nitriles - therapeutic use; rhabdomyosarcoma; Rhabdomyosarcoma, Embryonal - pathology; Stomach - pathology; treatment; Triazoles - therapeutic use; Uterine Neoplasms - pathology; uterus; Uterus - pathology
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/j.1447-0756.2008.00915.x

We describe a unique case of a 67‐year‐old patient with primary uterine rhabdomyosarcoma with a history of breast cancer and gastrointestinal stromal tumor of the stomach. Uterine rhabdomyosarcoma was diagnosed in our patient during adjuvant treatment of breast cancer with anastrozole. To the best of our knowledge, the development of primary uterine rhabdomyosarcoma has never been described in patients treated with anastrozole. Due to the suggested causative role of tamoxifen in the development of uterine sarcomas, it is interesting to analyze whether the new drug, anastrozole, exerts any pathogenic effect on the development of uterine sarocomas.