Association between gastric cancer and the Kyoto classification of gastritis

• Published in: Journal of gastroenterology and hepatology Vol. 32; no. 9; pp. 1581 - 1586
• Main Authors: Shichijo, Satoki, Hirata, Yoshihiro, Niikura, Ryota, Hayakawa, Yoku, Yamada, Atsuo, Koike, Kazuhiko
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.09.2017
• Subjects: Age Factors; Aged; Aged, 80 and over; Atrophy; Biopsy; Classification; Cross-Sectional Studies; endoscopic findings; Endoscopy; Endoscopy, Digestive System; Female; Gastric cancer; Gastric Mucosa - pathology; Gastritis; Gastritis - classification; Gastritis - complications; Gastritis - pathology; Humans; Intestinal Mucosa - pathology; Intestine; Kyoto classification; Male; Metaplasia; Middle Aged; Multivariate analysis; Risk; Risk Factors; Severity of Illness Index; Sex Factors; Stomach Neoplasms - etiology; Stomach Neoplasms - pathology; Kyoto classification; atrophy; endoscopic findings; gastric cancer
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/jgh.13764

Background and Aim Histological gastritis is associated with gastric cancer, but its diagnosis requires biopsy. Many classifications of endoscopic gastritis are available, but not all are useful for risk stratification of gastric cancer. The Kyoto Classification of Gastritis was proposed at the 85th Congress of the Japan Gastroenterological Endoscopy Society. This cross‐sectional study evaluated the usefulness of the Kyoto Classification of Gastritis for risk stratification of gastric cancer. Methods From August 2013 to September 2014, esophagogastroduodenoscopy was performed and the gastric findings evaluated according to the Kyoto Classification of Gastritis in a total of 4062 patients. The following five endoscopic findings were selected based on previous reports: atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness. Results A total of 3392 patients (1746 [51%] men and 1646 [49%] women) were analyzed. Among them, 107 gastric cancers were diagnosed. Atrophy was found in 2585 (78%) and intestinal metaplasia in 924 (27%). Enlarged folds, nodularity, and diffuse redness were found in 197 (5.8%), 22 (0.6%), and 573 (17%), respectively. In univariate analyses, the severity of atrophy, intestinal metaplasia, diffuse redness, age, and male sex were associated with gastric cancer. In a multivariate analysis, atrophy and male sex were found to be independent risk factors. Younger age and severe atrophy were determined to be associated with diffuse‐type gastric cancer. Conclusion Endoscopic detection of atrophy was associated with the risk of gastric cancer. Thus, patients with severe atrophy should be examined carefully and may require intensive follow‐up.